Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034385488> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2034385488 endingPage "2880" @default.
- W2034385488 startingPage "2874" @default.
- W2034385488 abstract "The purpose of this study was to compare the gastric acid inhibitory ability of increasing doses of intravenous (i.i.) pantoprazole with that of i.v. famotidine and placebo. Pentagastrin was infused continuously in healthy subjects as a model for patients with Zollinger-Ellison syndrome.Pentagastrin (1 microg/kg/h) was infused to stimulate maximum acid output in 39 subjects over a 25-h period. After 60 min of pentagastrin infusion, subjects received a single dose of i.v. pantoprazole (20, 40, 80, or 120 mg), i.v. famotidine (20 mg), or saline placebo. The variables measured were onset of response (time until acid output fell to < 10 mEq/h), duration of response (time acid output remained < 10 mEq/h), and cumulative acid output over 24 h.All doses of i.v. pantoprazole produced a dose-dependent suppression of acid output to < 10 mEq/h. Single i.v. doses of pantoprazole, 80 and 120 mg, suppressed acid output by > 90% in all subjects for < or = 21 h and had an onset of action of < 1 h.Intravenous pantoprazole has a rapid onset and a clear dose-related effect, with a significantly longer duration of action than that of i.v. famotidine." @default.
- W2034385488 created "2016-06-24" @default.
- W2034385488 creator A5010634985 @default.
- W2034385488 creator A5037146588 @default.
- W2034385488 creator A5053117866 @default.
- W2034385488 creator A5056564413 @default.
- W2034385488 creator A5066465250 @default.
- W2034385488 creator A5091680206 @default.
- W2034385488 date "1999-10-01" @default.
- W2034385488 modified "2023-10-03" @default.
- W2034385488 title "Inhibition of Pentagastrin-Induced Gastric Acid Secretion by Intravenous Pantoprazole: A Dose-Response Study" @default.
- W2034385488 cites W1606669771 @default.
- W2034385488 cites W1923168725 @default.
- W2034385488 cites W1979053258 @default.
- W2034385488 cites W1982930950 @default.
- W2034385488 cites W1991301757 @default.
- W2034385488 cites W1998652701 @default.
- W2034385488 cites W2003157753 @default.
- W2034385488 cites W2008804304 @default.
- W2034385488 cites W2011956055 @default.
- W2034385488 cites W2024520058 @default.
- W2034385488 cites W2036756177 @default.
- W2034385488 cites W2037884591 @default.
- W2034385488 cites W2057913578 @default.
- W2034385488 cites W2060576573 @default.
- W2034385488 cites W2064231495 @default.
- W2034385488 cites W2065250585 @default.
- W2034385488 cites W2120460133 @default.
- W2034385488 cites W2468469070 @default.
- W2034385488 cites W4238187763 @default.
- W2034385488 cites W4323254827 @default.
- W2034385488 doi "https://doi.org/10.1111/j.1572-0241.1999.01430.x" @default.
- W2034385488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10520836" @default.
- W2034385488 hasPublicationYear "1999" @default.
- W2034385488 type Work @default.
- W2034385488 sameAs 2034385488 @default.
- W2034385488 citedByCount "33" @default.
- W2034385488 countsByYear W20343854882012 @default.
- W2034385488 countsByYear W20343854882015 @default.
- W2034385488 crossrefType "journal-article" @default.
- W2034385488 hasAuthorship W2034385488A5010634985 @default.
- W2034385488 hasAuthorship W2034385488A5037146588 @default.
- W2034385488 hasAuthorship W2034385488A5053117866 @default.
- W2034385488 hasAuthorship W2034385488A5056564413 @default.
- W2034385488 hasAuthorship W2034385488A5066465250 @default.
- W2034385488 hasAuthorship W2034385488A5091680206 @default.
- W2034385488 hasConcept C126322002 @default.
- W2034385488 hasConcept C134018914 @default.
- W2034385488 hasConcept C142724271 @default.
- W2034385488 hasConcept C204787440 @default.
- W2034385488 hasConcept C27081682 @default.
- W2034385488 hasConcept C2777397205 @default.
- W2034385488 hasConcept C2777498785 @default.
- W2034385488 hasConcept C2777504413 @default.
- W2034385488 hasConcept C2779377912 @default.
- W2034385488 hasConcept C2779422922 @default.
- W2034385488 hasConcept C2781263782 @default.
- W2034385488 hasConcept C2781315423 @default.
- W2034385488 hasConcept C71924100 @default.
- W2034385488 hasConcept C79410662 @default.
- W2034385488 hasConceptScore W2034385488C126322002 @default.
- W2034385488 hasConceptScore W2034385488C134018914 @default.
- W2034385488 hasConceptScore W2034385488C142724271 @default.
- W2034385488 hasConceptScore W2034385488C204787440 @default.
- W2034385488 hasConceptScore W2034385488C27081682 @default.
- W2034385488 hasConceptScore W2034385488C2777397205 @default.
- W2034385488 hasConceptScore W2034385488C2777498785 @default.
- W2034385488 hasConceptScore W2034385488C2777504413 @default.
- W2034385488 hasConceptScore W2034385488C2779377912 @default.
- W2034385488 hasConceptScore W2034385488C2779422922 @default.
- W2034385488 hasConceptScore W2034385488C2781263782 @default.
- W2034385488 hasConceptScore W2034385488C2781315423 @default.
- W2034385488 hasConceptScore W2034385488C71924100 @default.
- W2034385488 hasConceptScore W2034385488C79410662 @default.
- W2034385488 hasIssue "10" @default.
- W2034385488 hasLocation W20343854881 @default.
- W2034385488 hasLocation W20343854882 @default.
- W2034385488 hasOpenAccess W2034385488 @default.
- W2034385488 hasPrimaryLocation W20343854881 @default.
- W2034385488 hasRelatedWork W1965345495 @default.
- W2034385488 hasRelatedWork W1971854684 @default.
- W2034385488 hasRelatedWork W1973606441 @default.
- W2034385488 hasRelatedWork W2019971016 @default.
- W2034385488 hasRelatedWork W2034385488 @default.
- W2034385488 hasRelatedWork W2056454041 @default.
- W2034385488 hasRelatedWork W2087283918 @default.
- W2034385488 hasRelatedWork W2132352178 @default.
- W2034385488 hasRelatedWork W2139517640 @default.
- W2034385488 hasRelatedWork W4255247287 @default.
- W2034385488 hasVolume "94" @default.
- W2034385488 isParatext "false" @default.
- W2034385488 isRetracted "false" @default.
- W2034385488 magId "2034385488" @default.
- W2034385488 workType "article" @default.