FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034386316> ?p ?o ?g. }

• W2034386316 endingPage "402" @default.
• W2034386316 startingPage "389" @default.
• W2034386316 abstract "In vertebrates, most glycinergic inhibitory neurons discharge phasically at a relatively low frequency. Such a pattern of glycine liberation from presynaptic terminals may affect the kinetics of post-synaptic glycine receptors. To examine this influence, we have analyzed the behavior of glycine receptors in response to repetitive stimulation at frequencies at which consecutive outside-out currents did not superimpose (0.5–4 Hz). Neurotransmitter release was mimicked on outside-out patches from zebrafish hindbrain Mauthner cells using fast flow application techniques. The amplitude of outside-out currents evoked by short (1 ms) repetitive applications of a saturating concentration (3 mM) of glycine remained unchanged for application frequencies ≤1 Hz. When the application frequency was increased from 1 to 4 Hz, the amplitude of the outside-out currents decreased with time to reach a steady state level. This decrease in current amplitude was larger and occurred faster with increasing application frequencies. Recovery occurred when the stimulation frequency was decreased back to 1 Hz. The recovery time constant was independent on the application frequency. This frequency-dependent inhibition was also observed for non-saturating glycine concentrations. Our results indicate that glycine receptor activity is down-regulated when the stimulation frequency increases to values >1 Hz. Glycine-evoked current simulations using a simple Markov model describing zebrafish glycine receptor kinetic behavior, indicates that this down-regulation of glycine receptor efficacy is due to a progressive accumulation of the receptors in a long lasting desensitization state. Our simulations suggest that this down-regulation can occur even when spontaneous inhibitory currents were generated randomly at a frequency >1 Hz." @default.
• W2034386316 created "2016-06-24" @default.
• W2034386316 creator A5046298509 @default.
• W2034386316 creator A5055029223 @default.
• W2034386316 date "2006-01-01" @default.
• W2034386316 modified "2023-10-18" @default.
• W2034386316 title "Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain" @default.
• W2034386316 cites W1971668441 @default.
• W2034386316 cites W1975810287 @default.
• W2034386316 cites W1976269567 @default.
• W2034386316 cites W1981111905 @default.
• W2034386316 cites W1991754155 @default.
• W2034386316 cites W2005829345 @default.
• W2034386316 cites W2007212380 @default.
• W2034386316 cites W2009667219 @default.
• W2034386316 cites W2015405439 @default.
• W2034386316 cites W2043385322 @default.
• W2034386316 cites W2058883143 @default.
• W2034386316 cites W2065545976 @default.
• W2034386316 cites W2065998952 @default.
• W2034386316 cites W2066562577 @default.
• W2034386316 cites W2066857405 @default.
• W2034386316 cites W2079066138 @default.
• W2034386316 cites W2102251534 @default.
• W2034386316 cites W2104004306 @default.
• W2034386316 cites W2106007968 @default.
• W2034386316 cites W2109417264 @default.
• W2034386316 cites W2111832360 @default.
• W2034386316 cites W2121480306 @default.
• W2034386316 cites W2133652497 @default.
• W2034386316 cites W2146138778 @default.
• W2034386316 cites W2152052384 @default.
• W2034386316 cites W2203599756 @default.
• W2034386316 cites W2226187382 @default.
• W2034386316 cites W2230402355 @default.
• W2034386316 cites W2245630575 @default.
• W2034386316 cites W2265550209 @default.
• W2034386316 cites W2412205269 @default.
• W2034386316 cites W2413277475 @default.
• W2034386316 cites W2427054186 @default.
• W2034386316 cites W2463137080 @default.
• W2034386316 cites W4295682975 @default.
• W2034386316 cites W4313635088 @default.
• W2034386316 doi "https://doi.org/10.1016/j.neuroscience.2006.01.057" @default.
• W2034386316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16564635" @default.
• W2034386316 hasPublicationYear "2006" @default.
• W2034386316 type Work @default.
• W2034386316 sameAs 2034386316 @default.
• W2034386316 citedByCount "13" @default.
• W2034386316 countsByYear W20343863162012 @default.
• W2034386316 countsByYear W20343863162014 @default.
• W2034386316 countsByYear W20343863162016 @default.
• W2034386316 countsByYear W20343863162017 @default.
• W2034386316 countsByYear W20343863162020 @default.
• W2034386316 crossrefType "journal-article" @default.
• W2034386316 hasAuthorship W2034386316A5046298509 @default.
• W2034386316 hasAuthorship W2034386316A5055029223 @default.
• W2034386316 hasBestOaLocation W20343863162 @default.
• W2034386316 hasConcept C12554922 @default.
• W2034386316 hasConcept C156927020 @default.
• W2034386316 hasConcept C169760540 @default.
• W2034386316 hasConcept C170493617 @default.
• W2034386316 hasConcept C17077164 @default.
• W2034386316 hasConcept C185592680 @default.
• W2034386316 hasConcept C24998067 @default.
• W2034386316 hasConcept C2776219046 @default.
• W2034386316 hasConcept C2777756961 @default.
• W2034386316 hasConcept C35599011 @default.
• W2034386316 hasConcept C515207424 @default.
• W2034386316 hasConcept C55493867 @default.
• W2034386316 hasConcept C86803240 @default.
• W2034386316 hasConceptScore W2034386316C12554922 @default.
• W2034386316 hasConceptScore W2034386316C156927020 @default.
• W2034386316 hasConceptScore W2034386316C169760540 @default.
• W2034386316 hasConceptScore W2034386316C170493617 @default.
• W2034386316 hasConceptScore W2034386316C17077164 @default.
• W2034386316 hasConceptScore W2034386316C185592680 @default.
• W2034386316 hasConceptScore W2034386316C24998067 @default.
• W2034386316 hasConceptScore W2034386316C2776219046 @default.
• W2034386316 hasConceptScore W2034386316C2777756961 @default.
• W2034386316 hasConceptScore W2034386316C35599011 @default.
• W2034386316 hasConceptScore W2034386316C515207424 @default.
• W2034386316 hasConceptScore W2034386316C55493867 @default.
• W2034386316 hasConceptScore W2034386316C86803240 @default.
• W2034386316 hasIssue "2" @default.
• W2034386316 hasLocation W20343863161 @default.
• W2034386316 hasLocation W20343863162 @default.
• W2034386316 hasLocation W20343863163 @default.
• W2034386316 hasLocation W20343863164 @default.
• W2034386316 hasLocation W20343863165 @default.
• W2034386316 hasLocation W20343863166 @default.
• W2034386316 hasLocation W20343863167 @default.
• W2034386316 hasOpenAccess W2034386316 @default.
• W2034386316 hasPrimaryLocation W20343863161 @default.
• W2034386316 hasRelatedWork W1558357192 @default.
• W2034386316 hasRelatedWork W1968788686 @default.
• W2034386316 hasRelatedWork W1987816196 @default.
• W2034386316 hasRelatedWork W1989659293 @default.

• next