FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034386687> ?p ?o ?g. }

• W2034386687 endingPage "185" @default.
• W2034386687 startingPage "179" @default.
• W2034386687 abstract "The possible role of mast cell chymase in organ fibrosis was examined using a bleomycin-induced pulmonary fibrosis model in mice. Intratracheal injection of bleomycin to mice significantly increased not only hydroxyproline content but also chymase activity in the lung. Administration of a chymase inhibitor SUN C8077 (7-chloro-3-(3-amynophenyl) quinazoline-2, 4-dione methanesulfonate) dose-dependently reversed the bleomycin-induced increase in hydroxyproline content as well as chymase activity in the lung. Human chymase digested latent transforming growth factor-β1 (TGF-β1) to form mature TGF-β1 in vitro, which was inhibited by SUN C8077. Human chymase, on the other hand, failed to stimulate DNA synthesis of human lung fibroblasts CCD-8Lu and LL97A. Taken together, it is suggested that mast cell chymase might participate in the pathogenesis of pulmonary fibrosis, and that the chymase-induced fibrosis might be mediated at least in part by TGF-β1. Chymase inhibitor may be promising for treatment of pulmonary fibrosis in humans." @default.
• W2034386687 created "2016-06-24" @default.
• W2034386687 creator A5020086230 @default.
• W2034386687 creator A5025321878 @default.
• W2034386687 creator A5054312361 @default.
• W2034386687 creator A5055828455 @default.
• W2034386687 creator A5071827485 @default.
• W2034386687 creator A5082174241 @default.
• W2034386687 creator A5082288167 @default.
• W2034386687 creator A5085552640 @default.
• W2034386687 date "2003-10-01" @default.
• W2034386687 modified "2023-10-16" @default.
• W2034386687 title "Involvement of mast cell chymase in bleomycin-induced pulmonary fibrosis in mice" @default.
• W2034386687 cites W1494869776 @default.
• W2034386687 cites W1521804991 @default.
• W2034386687 cites W1919288830 @default.
• W2034386687 cites W1972576054 @default.
• W2034386687 cites W1973586218 @default.
• W2034386687 cites W1987014468 @default.
• W2034386687 cites W1998499202 @default.
• W2034386687 cites W2000708019 @default.
• W2034386687 cites W2056835508 @default.
• W2034386687 cites W2058278041 @default.
• W2034386687 cites W2065506976 @default.
• W2034386687 cites W2072315546 @default.
• W2034386687 cites W2082725327 @default.
• W2034386687 cites W2087372716 @default.
• W2034386687 cites W2087423465 @default.
• W2034386687 cites W2088272869 @default.
• W2034386687 cites W2092192482 @default.
• W2034386687 cites W2103583995 @default.
• W2034386687 cites W2115554448 @default.
• W2034386687 cites W2122081319 @default.
• W2034386687 cites W2127838228 @default.
• W2034386687 cites W2128819566 @default.
• W2034386687 cites W2148210644 @default.
• W2034386687 cites W2151376215 @default.
• W2034386687 cites W2155326631 @default.
• W2034386687 cites W2160001887 @default.
• W2034386687 cites W2164260706 @default.
• W2034386687 cites W4241337787 @default.
• W2034386687 doi "https://doi.org/10.1016/j.ejphar.2003.08.050" @default.
• W2034386687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14575803" @default.
• W2034386687 hasPublicationYear "2003" @default.
• W2034386687 type Work @default.
• W2034386687 sameAs 2034386687 @default.
• W2034386687 citedByCount "56" @default.
• W2034386687 countsByYear W20343866872012 @default.
• W2034386687 countsByYear W20343866872013 @default.
• W2034386687 countsByYear W20343866872014 @default.
• W2034386687 countsByYear W20343866872015 @default.
• W2034386687 countsByYear W20343866872016 @default.
• W2034386687 countsByYear W20343866872018 @default.
• W2034386687 countsByYear W20343866872020 @default.
• W2034386687 countsByYear W20343866872021 @default.
• W2034386687 countsByYear W20343866872023 @default.
• W2034386687 crossrefType "journal-article" @default.
• W2034386687 hasAuthorship W2034386687A5020086230 @default.
• W2034386687 hasAuthorship W2034386687A5025321878 @default.
• W2034386687 hasAuthorship W2034386687A5054312361 @default.
• W2034386687 hasAuthorship W2034386687A5055828455 @default.
• W2034386687 hasAuthorship W2034386687A5071827485 @default.
• W2034386687 hasAuthorship W2034386687A5082174241 @default.
• W2034386687 hasAuthorship W2034386687A5082288167 @default.
• W2034386687 hasAuthorship W2034386687A5085552640 @default.
• W2034386687 hasConcept C126322002 @default.
• W2034386687 hasConcept C134018914 @default.
• W2034386687 hasConcept C142724271 @default.
• W2034386687 hasConcept C185592680 @default.
• W2034386687 hasConcept C203014093 @default.
• W2034386687 hasConcept C2776232574 @default.
• W2034386687 hasConcept C2776694085 @default.
• W2034386687 hasConcept C2777714996 @default.
• W2034386687 hasConcept C2779726688 @default.
• W2034386687 hasConcept C2779797417 @default.
• W2034386687 hasConcept C2780559512 @default.
• W2034386687 hasConcept C2780614898 @default.
• W2034386687 hasConcept C2781244666 @default.
• W2034386687 hasConcept C502942594 @default.
• W2034386687 hasConcept C71924100 @default.
• W2034386687 hasConceptScore W2034386687C126322002 @default.
• W2034386687 hasConceptScore W2034386687C134018914 @default.
• W2034386687 hasConceptScore W2034386687C142724271 @default.
• W2034386687 hasConceptScore W2034386687C185592680 @default.
• W2034386687 hasConceptScore W2034386687C203014093 @default.
• W2034386687 hasConceptScore W2034386687C2776232574 @default.
• W2034386687 hasConceptScore W2034386687C2776694085 @default.
• W2034386687 hasConceptScore W2034386687C2777714996 @default.
• W2034386687 hasConceptScore W2034386687C2779726688 @default.
• W2034386687 hasConceptScore W2034386687C2779797417 @default.
• W2034386687 hasConceptScore W2034386687C2780559512 @default.
• W2034386687 hasConceptScore W2034386687C2780614898 @default.
• W2034386687 hasConceptScore W2034386687C2781244666 @default.
• W2034386687 hasConceptScore W2034386687C502942594 @default.
• W2034386687 hasConceptScore W2034386687C71924100 @default.
• W2034386687 hasIssue "2-3" @default.
• W2034386687 hasLocation W20343866871 @default.
• W2034386687 hasLocation W20343866872 @default.

• next