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- W2034387394 abstract "The purpose of this study was to develop a suitable in vitro model system to study the biochemical pathway(s) by which interleukin-1beta (IL-1beta) contributes to the pathogenesis of cerebral ischemia. Thus, the effect of IL-1beta on a number of injury paradigms associated with energy deprivation was investigated using murine mixed cortical cell cultures. While IL-1beta by itself was not neurotoxic, pre-treatment-but not concurrent or post-treatment-with this cytokine potentiated neuronal injury induced by depriving cultures of either oxygen, glucose, or both oxygen and glucose. Cytotoxicity was abolished by an IL-1beta-neutralizing antibody. Together, these results demonstrate the establishment of reliable and reproducible in vitro models that will now allow detailed investigation of the cellular and molecular mechanisms relating to IL-1beta-mediated neuronal cell death." @default.
- W2034387394 created "2016-06-24" @default.
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- W2034387394 date "2005-04-01" @default.
- W2034387394 modified "2023-10-06" @default.
- W2034387394 title "Interleukin-1β potentiates neuronal injury in a variety of injury models involving energy deprivation" @default.
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- W2034387394 doi "https://doi.org/10.1016/j.jneuroim.2004.12.007" @default.
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