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• W2034387476 abstract "The ‘immune privilege’ of the central nervous system (CNS) is indispensable for damage limitation during inflammation in a sensitive organ with poor regenerative capacity. It is a longstanding notion which, over time, has acquired several misconceptions and a lack of precision in its definition. In this article, we address these issues and re-define CNS immune privilege in the light of recent data. We show how it is far from absolute, and how it varies with age and brain region. Immune privilege in the CNS is often mis-attributed wholly to the blood–brain barrier. We discuss the pivotal role of the specialization of the afferent arm of adaptive immunity in the brain, which results in a lack of cell-mediated antigen drainage to the cervical lymph nodes although soluble drainage to these nodes is well described. It is now increasingly recognized how immune privilege is maintained actively as a result of the immunoregulatory characteristics of the CNS-resident cells and their microenvironment. The ‘immune privilege’ of the central nervous system (CNS) is indispensable for damage limitation during inflammation in a sensitive organ with poor regenerative capacity. It is a longstanding notion which, over time, has acquired several misconceptions and a lack of precision in its definition. In this article, we address these issues and re-define CNS immune privilege in the light of recent data. We show how it is far from absolute, and how it varies with age and brain region. Immune privilege in the CNS is often mis-attributed wholly to the blood–brain barrier. We discuss the pivotal role of the specialization of the afferent arm of adaptive immunity in the brain, which results in a lack of cell-mediated antigen drainage to the cervical lymph nodes although soluble drainage to these nodes is well described. It is now increasingly recognized how immune privilege is maintained actively as a result of the immunoregulatory characteristics of the CNS-resident cells and their microenvironment." @default.
• W2034387476 created "2016-06-24" @default.
• W2034387476 creator A5022920379 @default.
• W2034387476 creator A5038952654 @default.
• W2034387476 creator A5044019815 @default.
• W2034387476 date "2007-01-01" @default.
• W2034387476 modified "2023-10-11" @default.
• W2034387476 title "What is immune privilege (not)?" @default.
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• W2034387476 doi "https://doi.org/10.1016/j.it.2006.11.004" @default.
• W2034387476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17129764" @default.
• W2034387476 hasPublicationYear "2007" @default.
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