FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034387495> ?p ?o ?g. }

• W2034387495 endingPage "412" @default.
• W2034387495 startingPage "407" @default.
• W2034387495 abstract "Functional adaptation of the mouse ulna in response to artificial loading in vivo was assessed using a technique previously developed in the rat. Strain gauge recordings from the mouse ulnar midshaft during locomotion showed peak strains of 1680 muepsilon and maximum strain rates of 0.03 sec(-1). During falls from 20 cm these reached 2620 muepsilon and 0.10 sec(-1). Axial loads of 3.0 N and 4.3 N, applied through the olecranon and flexed carpus, engendered peak strains at the lateral ulnar midshaft of 2000 muepsilon and 3000 muepsilon, respectively. The left ulnae of 17, 17-week-old female CD1 mice were loaded for 10 min with a 4 Hz trapezoidal wave engendering a strain rate of 0.1 sec(-1) for 5 days/week for 2 weeks. The mice were killed 3 days later. The response of the cortical bone of the diaphysis was assessed histomorphometrically using double calcein labels administered on days 3 and 12 of the loading period. Loading to peak strains of 2000 muepsilon stimulated lamellar periosteal bone formation, but no response endosteally. The greatest increase in cortical bone area was 4 mm distal to the midshaft (5 +/- 0.4% compared with 0.1 +/- 0.1% in controls [p < 0.01]). Periosteal bone formation rate (BFR) at this site was 0.73 +/- 0.06 microm(2)/microm per day, compared with 0.03 +/- 0.02 microm(2)/microm per day in controls (p < 0.01). Loading to peak strains of 3000 muepsilon induced a mixed woven/lamellar periosteal response and lamellar endosteal bone formation. Both of these were greatest 3-4 mm distal to the ulnar midshaft. At this level, the loading-induced periosteal response increased cortical bone area by 21 +/- 4% compared with 0.03 +/- 0.02% in controls, and resulted in a BFR of 2.84 +/- 0.42 microm(2)/microm per day, compared with 0.01 +/- 0.01 microm(2)/microm per day in controls (p < 0.05). Endosteal new bone formation resulted in a 2 +/- 0.4% increase in cortical bone area, compared with 0.4 +/- 0.3% in controls, and a BFR of 1.05 +/- 0.23 microm(2)/microm per day, compared with 0.22 +/- 0.15 microm(2)/microm per day in controls (p < 0.05). These data show that the axial ulna loading technique developed in the rat can be used successfully in the mouse. As in the rat, a short daily period of loading results in an osteogenic response related to peak strain magnitude. One important advantage in using mice over rats involves the potential for assessing the effects of loading in transgenics." @default.
• W2034387495 created "2016-06-24" @default.
• W2034387495 creator A5017902807 @default.
• W2034387495 creator A5038422391 @default.
• W2034387495 creator A5039414872 @default.
• W2034387495 date "2002-09-01" @default.
• W2034387495 modified "2023-09-25" @default.
• W2034387495 title "Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading" @default.
• W2034387495 cites W1486376581 @default.
• W2034387495 cites W1557587894 @default.
• W2034387495 cites W1875886495 @default.
• W2034387495 cites W1980216638 @default.
• W2034387495 cites W1982563976 @default.
• W2034387495 cites W1986934120 @default.
• W2034387495 cites W1995972008 @default.
• W2034387495 cites W1996664794 @default.
• W2034387495 cites W1997899363 @default.
• W2034387495 cites W1999320000 @default.
• W2034387495 cites W2000004772 @default.
• W2034387495 cites W2007438632 @default.
• W2034387495 cites W2011404595 @default.
• W2034387495 cites W2014209332 @default.
• W2034387495 cites W2017472612 @default.
• W2034387495 cites W2018676472 @default.
• W2034387495 cites W2023987420 @default.
• W2034387495 cites W2027237953 @default.
• W2034387495 cites W2035035957 @default.
• W2034387495 cites W2035642064 @default.
• W2034387495 cites W2049077961 @default.
• W2034387495 cites W2050684881 @default.
• W2034387495 cites W2051917629 @default.
• W2034387495 cites W2055495715 @default.
• W2034387495 cites W2057330900 @default.
• W2034387495 cites W2057783221 @default.
• W2034387495 cites W2060297934 @default.
• W2034387495 cites W2064691832 @default.
• W2034387495 cites W2069613012 @default.
• W2034387495 cites W2075149537 @default.
• W2034387495 cites W2075262429 @default.
• W2034387495 cites W2084579646 @default.
• W2034387495 cites W2084872529 @default.
• W2034387495 cites W2086005052 @default.
• W2034387495 cites W2087378917 @default.
• W2034387495 cites W2090303791 @default.
• W2034387495 cites W2093509637 @default.
• W2034387495 cites W2107348178 @default.
• W2034387495 cites W2114495080 @default.
• W2034387495 cites W2114528551 @default.
• W2034387495 cites W2117994161 @default.
• W2034387495 cites W2121780717 @default.
• W2034387495 cites W2130934825 @default.
• W2034387495 cites W2130991286 @default.
• W2034387495 cites W2143354597 @default.
• W2034387495 cites W2145937652 @default.
• W2034387495 cites W2155937147 @default.
• W2034387495 cites W4235057420 @default.
• W2034387495 cites W4247889657 @default.
• W2034387495 cites W4254972920 @default.
• W2034387495 cites W92621236 @default.
• W2034387495 doi "https://doi.org/10.1016/s8756-3282(02)00842-6" @default.
• W2034387495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12231414" @default.
• W2034387495 hasPublicationYear "2002" @default.
• W2034387495 type Work @default.
• W2034387495 sameAs 2034387495 @default.
• W2034387495 citedByCount "160" @default.
• W2034387495 countsByYear W20343874952012 @default.
• W2034387495 countsByYear W20343874952013 @default.
• W2034387495 countsByYear W20343874952014 @default.
• W2034387495 countsByYear W20343874952015 @default.
• W2034387495 countsByYear W20343874952016 @default.
• W2034387495 countsByYear W20343874952017 @default.
• W2034387495 countsByYear W20343874952018 @default.
• W2034387495 countsByYear W20343874952019 @default.
• W2034387495 countsByYear W20343874952020 @default.
• W2034387495 countsByYear W20343874952021 @default.
• W2034387495 countsByYear W20343874952022 @default.
• W2034387495 countsByYear W20343874952023 @default.
• W2034387495 crossrefType "journal-article" @default.
• W2034387495 hasAuthorship W2034387495A5017902807 @default.
• W2034387495 hasAuthorship W2034387495A5038422391 @default.
• W2034387495 hasAuthorship W2034387495A5039414872 @default.
• W2034387495 hasConcept C105702510 @default.
• W2034387495 hasConcept C141071460 @default.
• W2034387495 hasConcept C149342994 @default.
• W2034387495 hasConcept C159985019 @default.
• W2034387495 hasConcept C185592680 @default.
• W2034387495 hasConcept C192562407 @default.
• W2034387495 hasConcept C2777695862 @default.
• W2034387495 hasConcept C2778022156 @default.
• W2034387495 hasConcept C2778951355 @default.
• W2034387495 hasConcept C2780554211 @default.
• W2034387495 hasConcept C2780711802 @default.
• W2034387495 hasConcept C2781184374 @default.
• W2034387495 hasConcept C2781451080 @default.
• W2034387495 hasConcept C71924100 @default.
• W2034387495 hasConceptScore W2034387495C105702510 @default.
• W2034387495 hasConceptScore W2034387495C141071460 @default.
• W2034387495 hasConceptScore W2034387495C149342994 @default.

• next