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- W2034388764 abstract "Abstract Severed axons of the inferior colliculus (IC) commissure can regenerate across a lesion in organotypic cultures from postnatal day (P) 6 gerbils, but this regenerative capacity is lost by P12 (Hafidi et al. [ 1995 ] J Neurosci 15:1298–1307, [1999] J Neurobiol 41:267–280). In the present study, we examined the mechanisms underlying this age‐dependent failure of axons to regenerate. In P6–P12 heterochronic cultures, the P12 axons failed to cross the lesion site and project to the contralateral P6 IC lobe. In contrast, axons originating from the P6 lobe could regenerate through the lesion and invade the contralateral P12 IC lobe. To determine whether this age‐dependent change in regenerative capacity can develop in organotypic cultures, IC slices with an intact commissure were obtained from P6 animals, grown in vitro for 6 days, and then lesioned at the commissure. In these slices, axon regeneration failure was similar to that observed in normal P12 tissue. Several in vitro treatments enhanced axon regeneration: removal of the entire midline region, inhibition of protein synthesis at the lesion site, and exposure to ABC chondroitinase. Furthermore, when the injured commissural axons were provided with a carpet of C6‐R cells (a radial glia‐like cell line), significantly more axons projected to the contralateral lobe of the IC. Taken together, these results suggest that the maturation of nonneuronal cells within the lesion site lead to failed axon regeneration in mature animals, and show that ameliorative strategies can be evaluated in vitro. J. Comp. Neurol. 470:80–92, 2004. © 2004 Wiley‐Liss, Inc." @default.
- W2034388764 created "2016-06-24" @default.
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- W2034388764 date "2004-01-23" @default.
- W2034388764 modified "2023-10-12" @default.
- W2034388764 title "In vitro analysis of mechanisms underlying age-dependent failure of axon regeneration" @default.
- W2034388764 cites W1500809101 @default.
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- W2034388764 cites W1635850624 @default.
- W2034388764 cites W1646378775 @default.
- W2034388764 cites W1760881456 @default.
- W2034388764 cites W1824808675 @default.
- W2034388764 cites W1859477582 @default.
- W2034388764 cites W1884076829 @default.
- W2034388764 cites W1952053031 @default.
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- W2034388764 cites W1971208141 @default.
- W2034388764 cites W1971469691 @default.
- W2034388764 cites W1975970393 @default.
- W2034388764 cites W1979447754 @default.
- W2034388764 cites W1980345345 @default.
- W2034388764 cites W1990346699 @default.
- W2034388764 cites W1990918954 @default.
- W2034388764 cites W1994767290 @default.
- W2034388764 cites W1998978807 @default.
- W2034388764 cites W1999531386 @default.
- W2034388764 cites W2009097826 @default.
- W2034388764 cites W2009870993 @default.
- W2034388764 cites W2011387965 @default.
- W2034388764 cites W2012928251 @default.
- W2034388764 cites W2013035816 @default.
- W2034388764 cites W2017847893 @default.
- W2034388764 cites W2019730170 @default.
- W2034388764 cites W2021186349 @default.
- W2034388764 cites W2022144987 @default.
- W2034388764 cites W2025778924 @default.
- W2034388764 cites W2027401084 @default.
- W2034388764 cites W2027759472 @default.
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- W2034388764 cites W2029373779 @default.
- W2034388764 cites W2029768920 @default.
- W2034388764 cites W2032304318 @default.
- W2034388764 cites W2037035554 @default.
- W2034388764 cites W2038248402 @default.
- W2034388764 cites W2039385392 @default.
- W2034388764 cites W2040051757 @default.
- W2034388764 cites W2043182675 @default.
- W2034388764 cites W2050823048 @default.
- W2034388764 cites W2053804461 @default.
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- W2034388764 cites W2083212123 @default.
- W2034388764 cites W2085431903 @default.
- W2034388764 cites W2086256856 @default.
- W2034388764 cites W2091404665 @default.
- W2034388764 cites W2092357265 @default.
- W2034388764 cites W2096673210 @default.
- W2034388764 cites W2097530133 @default.
- W2034388764 cites W2101996466 @default.
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- W2034388764 cites W2108129164 @default.
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- W2034388764 cites W2110836796 @default.
- W2034388764 cites W2116181102 @default.
- W2034388764 cites W2132352241 @default.
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- W2034388764 cites W2142509200 @default.
- W2034388764 cites W2146191546 @default.
- W2034388764 cites W2147786624 @default.
- W2034388764 cites W2395631443 @default.
- W2034388764 cites W4245284413 @default.
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- W2034388764 doi "https://doi.org/10.1002/cne.20003" @default.
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- W2034388764 hasPublicationYear "2004" @default.
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