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• W2034389296 abstract "An in vitro mononuclear cell system to model the microenvironment of coinfection with HIV-1 and Mycobacterium tuberculosis (MTB) was developed. This cellular system was used to assess the interaction of MTB-infected monocytes and T cells from dually infected HIV-1/TB patients with pulmonary tuberculosis (TB). Subjects with higher induction of HIV-1 gag/pol mRNA expression after MTB stimulation had increased MTB-specific T cell IFN-γ and TNF-α production. Lack of HIV-1 mRNA induction did not correlate with increased induction of regulatory T cells (T-reg) as measured by MTB-induced Foxp3 mRNA. HIV-1 induction did not significantly correlate with clinical parameters including plasma HIV-1 viral load or CD4+ T cell count. These data model MTB-induced HIV-1 replication at the microenvironment of MTB reactivation/infection. The data suggest that the magnitude of MTB-specific T cell responses drives local viral pathogenesis regardless of the stage of HIV-1 disease as reflected by plasma viral load or CD4+ T cell count." @default.
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• W2034389296 date "2009-02-01" @default.
• W2034389296 modified "2023-10-18" @default.
• W2034389296 title "Induction of HIV Type 1 Expression Correlates with T Cell Responsiveness to Mycobacteria in Patients Coinfected with HIV Type 1 and Mycobacterium tuberculosis" @default.
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• W2034389296 doi "https://doi.org/10.1089/aid.2008.0182" @default.
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