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• W2034391314 abstract "Serous epithelial ovarian cancer (SEOC) is the most lethal gynecological cancer in the United States with disease recurrence being the major cause of morbidity and mortality. Despite recent advances in our understanding of the molecular mechanisms responsible for the development of SEOC, the survival rate for women with this disease has remained relatively unchanged in the last two decades. Preclinical mouse models of ovarian cancer, including xenograft, syngeneic, and genetically engineered mice, have been developed to provide a mechanism for studying the development and progression of SEOC. Such models strive to increase our understanding of the etiology and dissemination of ovarian cancer in order to overcome barriers to early detection and resistance to standard chemotherapy. Although there is not a single model that is most suitable for studying ovarian cancer, improvements have led to current models that more closely mimic human disease in their genotype and phenotype. Other advances in the field, such as live animal imaging techniques, allow effective monitoring of the microenvironment and therapeutic efficacy. New and improved preclinical mouse models, combined with technological advances to study such models, will undoubtedly render success of future human clinical trials for patients with SEOC." @default.
• W2034391314 created "2016-06-24" @default.
• W2034391314 creator A5028772864 @default.
• W2034391314 creator A5043029671 @default.
• W2034391314 creator A5059436422 @default.
• W2034391314 date "2014-01-01" @default.
• W2034391314 modified "2023-09-25" @default.
• W2034391314 title "Recent Technological Advances in Using Mouse Models to Study Ovarian Cancer" @default.
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• W2034391314 doi "https://doi.org/10.3389/fonc.2014.00026" @default.
• W2034391314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3923136" @default.
• W2034391314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24592355" @default.
• W2034391314 hasPublicationYear "2014" @default.
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