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• W2034392112 abstract "<b><i>Background/Aims: </i></b>Drug-induced acute kidney injury (AKI) has been a severe threat to hospitalized patients, raising the urgent needs to develop strategies to reduce AKI. We investigated the protective activity of <i>Dendropanax morbifera</i> (DP), a medicinal plant which has been widely used to treat infectious and pain diseases, on acute kidney injury (AKI) using cisplatin-induced nephropathic models. <b><i>Methods: </i></b>Both <i>in vitro</i> renal tubular cells (NRK-52E) and <i>in vivo</i> rat models were used to demonstrate the nephroprotective effect of DP. <b><i>Results: </i></b>Methanolic extract from DP significantly reduced cisplatin-induced toxicity in renal tubular cells. Through successive liquid extraction, the extract of DP was separated into n-hexane, CHCl₃, EtOAc, n-BuOH, and H₂O fractions. Among these, the CHCl₃ fraction (DPCF) was found to be most potent. The protective activity of DPCF was found to be mediated through anti-oxidant, mitochondrial protective, and anti-apoptotic activities. In <i>in vivo</i> rat models of AKI, treatment with DPCF significantly reversed the cisplatin-induced increase in blood urea nitrogen and serum creatinine and histopathologic damage, recovered the level of anti-oxidant enzymes, and inhibited renal apoptosis. <b><i>Conclusion: </i></b>We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage." @default.
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• W2034392112 date "2015-01-01" @default.
• W2034392112 modified "2023-09-30" @default.
• W2034392112 title "Protective Activity of <b><i>Dendropanax Morbifera</i></b> Against Cisplatin-Induced Acute Kidney Injury" @default.
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• W2034392112 doi "https://doi.org/10.1159/000368466" @default.
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