Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034394772> ?p ?o ?g. }
- W2034394772 endingPage "1705" @default.
- W2034394772 startingPage "1697" @default.
- W2034394772 abstract "<h3>Aim</h3> To test the efficiency of tumour necrosis factor blockers (adalimumab) in patients with painful refractory (non-responders to analgesics and non-steroidal anti-inflammatory drugs (NSAIDs)) hand osteoarthritis (OA). <h3>Methods</h3> We performed a randomised, double-blind, placebo-controlled, parallel group, multicentre study. Patients were randomised to: 1/1 adalimumab 40 mg for two subcutaneous injections at a 15-day interval or placebo and monitored for 6 months. The primary outcome was the percentage of patients with an improvement of more than 50% in global pain (Visual Analogue Scale) between week 0 (W0) and week 6 (W6). Secondary outcomes included the number of painful joints, swollen joints, morning stiffness duration, patient and practitioner global assessments, functional indexes for hand OA, and consumption of analgesics. Analysis on the mean primary outcome measure was done on patients who received at least one injection. <h3>Results</h3> 99 patients were recruited and 85 patients were randomised. Among them, 37 patients in the placebo group and 41 in the adalimumab group received at least one injection and were evaluated at W6 (n=78) on the main efficacy outcome. Mean age was 62 years, 85% were women, and mean level of pain was 62 mm at W0. At W6, 35.1% in the adalimumab group versus 27.3% in the placebo group had a pain reduction ≥50% (RR 1.12 (95% CI 0.82 to 1.54; p=0.48). There were no statistical differences for all secondary end points. The rate of adverse events was similar in the two groups. <h3>Conclusions</h3> Adalimumab was not superior to placebo to alleviate pain in patients with hand OA not responding to analgesics and NSAIDs. <h3>Trials registration number</h3> NCT00597623." @default.
- W2034394772 created "2016-06-24" @default.
- W2034394772 creator A5000032925 @default.
- W2034394772 creator A5018062347 @default.
- W2034394772 creator A5022620505 @default.
- W2034394772 creator A5026087145 @default.
- W2034394772 creator A5034097548 @default.
- W2034394772 creator A5034260852 @default.
- W2034394772 creator A5037584181 @default.
- W2034394772 creator A5049418442 @default.
- W2034394772 creator A5050180409 @default.
- W2034394772 creator A5051072252 @default.
- W2034394772 creator A5058962112 @default.
- W2034394772 creator A5062693223 @default.
- W2034394772 creator A5063666757 @default.
- W2034394772 creator A5084376077 @default.
- W2034394772 creator A5087935214 @default.
- W2034394772 date "2014-05-09" @default.
- W2034394772 modified "2023-10-09" @default.
- W2034394772 title "Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial" @default.
- W2034394772 cites W1980618271 @default.
- W2034394772 cites W1996939581 @default.
- W2034394772 cites W1997957358 @default.
- W2034394772 cites W2002152793 @default.
- W2034394772 cites W2009524387 @default.
- W2034394772 cites W2011487877 @default.
- W2034394772 cites W2014934138 @default.
- W2034394772 cites W2016671974 @default.
- W2034394772 cites W2017869529 @default.
- W2034394772 cites W2033370057 @default.
- W2034394772 cites W2036491373 @default.
- W2034394772 cites W2037044386 @default.
- W2034394772 cites W2040105893 @default.
- W2034394772 cites W2042604647 @default.
- W2034394772 cites W2049103906 @default.
- W2034394772 cites W2052483663 @default.
- W2034394772 cites W2053342448 @default.
- W2034394772 cites W2057491978 @default.
- W2034394772 cites W2066039815 @default.
- W2034394772 cites W2088119058 @default.
- W2034394772 cites W2090510984 @default.
- W2034394772 cites W2098049472 @default.
- W2034394772 cites W2113737049 @default.
- W2034394772 cites W2135956897 @default.
- W2034394772 cites W2135957139 @default.
- W2034394772 cites W2137674910 @default.
- W2034394772 cites W2137912043 @default.
- W2034394772 cites W2141363952 @default.
- W2034394772 cites W2144718078 @default.
- W2034394772 cites W2147650940 @default.
- W2034394772 cites W4230038400 @default.
- W2034394772 cites W4235252246 @default.
- W2034394772 cites W4237427043 @default.
- W2034394772 doi "https://doi.org/10.1136/annrheumdis-2014-205348" @default.
- W2034394772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24817417" @default.
- W2034394772 hasPublicationYear "2014" @default.
- W2034394772 type Work @default.
- W2034394772 sameAs 2034394772 @default.
- W2034394772 citedByCount "132" @default.
- W2034394772 countsByYear W20343947722014 @default.
- W2034394772 countsByYear W20343947722015 @default.
- W2034394772 countsByYear W20343947722016 @default.
- W2034394772 countsByYear W20343947722017 @default.
- W2034394772 countsByYear W20343947722018 @default.
- W2034394772 countsByYear W20343947722019 @default.
- W2034394772 countsByYear W20343947722020 @default.
- W2034394772 countsByYear W20343947722021 @default.
- W2034394772 countsByYear W20343947722022 @default.
- W2034394772 countsByYear W20343947722023 @default.
- W2034394772 crossrefType "journal-article" @default.
- W2034394772 hasAuthorship W2034394772A5000032925 @default.
- W2034394772 hasAuthorship W2034394772A5018062347 @default.
- W2034394772 hasAuthorship W2034394772A5022620505 @default.
- W2034394772 hasAuthorship W2034394772A5026087145 @default.
- W2034394772 hasAuthorship W2034394772A5034097548 @default.
- W2034394772 hasAuthorship W2034394772A5034260852 @default.
- W2034394772 hasAuthorship W2034394772A5037584181 @default.
- W2034394772 hasAuthorship W2034394772A5049418442 @default.
- W2034394772 hasAuthorship W2034394772A5050180409 @default.
- W2034394772 hasAuthorship W2034394772A5051072252 @default.
- W2034394772 hasAuthorship W2034394772A5058962112 @default.
- W2034394772 hasAuthorship W2034394772A5062693223 @default.
- W2034394772 hasAuthorship W2034394772A5063666757 @default.
- W2034394772 hasAuthorship W2034394772A5084376077 @default.
- W2034394772 hasAuthorship W2034394772A5087935214 @default.
- W2034394772 hasConcept C121332964 @default.
- W2034394772 hasConcept C126322002 @default.
- W2034394772 hasConcept C141071460 @default.
- W2034394772 hasConcept C14184104 @default.
- W2034394772 hasConcept C142424586 @default.
- W2034394772 hasConcept C142724271 @default.
- W2034394772 hasConcept C168563851 @default.
- W2034394772 hasConcept C197934379 @default.
- W2034394772 hasConcept C202061045 @default.
- W2034394772 hasConcept C204787440 @default.
- W2034394772 hasConcept C27081682 @default.
- W2034394772 hasConcept C2776164576 @default.
- W2034394772 hasConcept C2777575956 @default.