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• W2034397622 abstract "We studied the effects of a thromboxane A 2 receptor (TP receptor) antagonist, ICI‐192,605 (0.5 mg kg −1 , i.v.) and a selective thromboxane (Tx) synthetase inhibitor, OKY‐046 (30 mg kg −1 , i.v.), on airway responses induced by leukotriene D 4 (LTD 4 ; 0.2 nmol) or prostaglandin F 2α (PGF 2α ; 20 nmol) instilled via the airways route to anaesthetized guinea‐pigs. For a comparison, airway responses to a TxA 2 ‐mimetic, U‐46619 (0.02 nmol) were also studied. We measured both lung resistance (R L ) to monitor airflow obstruction, and extravasation of Evans Blue dye to quantify airway plasma exudation. Instilled LTD 4 into the tracheal lumen induced an immediate peak and subsequently persistent increase in R L and produced a large amount of extravasation of Evans Blue dye at all airway levels. Both ICI‐192,605 and OKY‐046 significantly attenuated the persistent increase in R L following the immediate response and reduced LTD 4 ‐induced extravasation of Evans Blue dye in the trachea and proximal intrapulmonary airway. Instilled LTD 4 produced significant increases in immunoreactive TxB 2 in bronchoalveolar lavage fluid obtained 1.5 min after instillation of LTD 4 . Instilled PGF 2α into the tracheal lumen induced an immediate increase in R L which peaked at approximately 15 s. We also observed a delayed sustained increase in R L , reaching a second peak at approximately 4 min. PGF 2α produced small but significant increases in the amount of Evans Blue dye at all airway levels. As with PGF 2α , instillation of U‐46619 produced a biphasic increase in R L and extravasation of Evans Blue dye. The potency of PGF 2α in inducing these airway responses was about 1000 times less than U‐46619. ICI‐192,605 abolished both the immediate and the delayed increase in R L after PGF 2α , and also blocked PGF 2α ‐induced extravasation of Evans Blue dye. However, OKY‐046 had no inhibitory effects on these responses. We conclude that airflow obstruction and airway plasma exudation induced by instilled LTD 4 is, in part, mediated via TxA 2 generation and subsequent activation of TP‐receptors. On the other hand, instilled PGF 2α , while inducing similar responses, does so primarily by direct activation of TP receptors, rather than via TxA 2 generation." @default.
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• W2034397622 date "1993-09-01" @default.
• W2034397622 modified "2023-10-17" @default.
• W2034397622 title "Leukotriene D4- and prostaglandin F2α-induced airflow obstruction and airway plasma exudation in guinea-pig: role of thromboxane and its receptor" @default.
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• W2034397622 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13781.x" @default.
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