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- W2034399129 abstract "Decreases in muscle strength and endurance frequently are observed in non-weight-bearing conditions such as bed rest, spaceflight or limb immobilization. PURPOSE: Our purpose was to determine if supine treadmill exercise against simulated gravity, by application of lower body negative pressure (LBNP), prevents loss of lean leg mass, strength and endurance during 30 d of 6° head-down bed rest (BR). METHODS: Fifteen pairs of monozygous twins (8 male, 7 female pairs; 26±4 yrs; 170±12 cm; 62.6±11.3 kg; mean±SD) were subjects in the present study. One sibling of each pair of twins was randomly assigned to either an exercise (EX) or non-exercise (CON) group. The EX twin walked/jogged on a vertical treadmill within LBNP chamber 6d·wk−1 using a 40-min interval exercise protocol at 40–80% of pre-BR VO2eak. LBNP was adjusted individually for each subject such that footward force was between 1.0 and 1.2 times body weight (−53±5 mmHg LBNP). The CON twin performed no exercise during BR. Subjects performed isokinetic knee (60 and 2Q°-sA and ankle (60°-s1) testing to assess strength and endurance (End) before and after BR. They also had their lean leg mass (L) evaluated by DEXA before and after BR. RESULTS: Changes in peak torque (Tk) were smaller for flexion (flex) than for extension (ext) after BR and did not differ between groups. The CON group had larger decreases (p <0.05) in Lmass, knee and ankle ext Tk, and knee ext End.TableCONCLUSIONS: This LBNP/exercise countermeasure prevented losses in lean leg mass and partially counteracted the decreases in knee and ankle extensor strength and in knee extensor endurance during 30 d of BR. To completely prevent changes in lower body strength, the addition of a resistive exercise countermeasure probably will be necessary." @default.
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- W2034399129 date "2006-05-01" @default.
- W2034399129 modified "2023-09-25" @default.
- W2034399129 title "Twins Bed Rest Project" @default.
- W2034399129 doi "https://doi.org/10.1249/00005768-200605001-02521" @default.
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