Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034399770> ?p ?o ?g. }
- W2034399770 endingPage "133" @default.
- W2034399770 startingPage "118" @default.
- W2034399770 abstract "Cellular receptors for KSHV attachment and entry were characterized using tyramide signal amplification (TSA)-enhanced confocal microscopy. Integrins αVβ3, αVβ5 and α3β1 were detected on essentially all the actin-based cell surface microdomains that initially bind KSHV, while the presence of CD98 and heparan sulfate (HS), the putative attachment receptor, was more variable. KSHV bound to the same cell surface microdomains with and without HS indicating that initial attachment of KSHV is not dependent on HS and that receptors other than HS can mediate attachment. A human salivary gland (HSG) epithelial line was identified, which lacks αVβ3 but expresses high levels of HS, α3β1 and other putative KSHV receptors. These cells were resistant to KSHV binding and infection. Reconstitution of cell surface αVβ3 rendered HSG cells highly susceptible to KSHV infection, demonstrating a critical role for αVβ3 in the binding and entry of KSHV that is not shared with other proposed receptors." @default.
- W2034399770 created "2016-06-24" @default.
- W2034399770 creator A5003858110 @default.
- W2034399770 creator A5015017695 @default.
- W2034399770 creator A5041974197 @default.
- W2034399770 creator A5060027930 @default.
- W2034399770 date "2014-09-01" @default.
- W2034399770 modified "2023-10-14" @default.
- W2034399770 title "KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate" @default.
- W2034399770 cites W1579891230 @default.
- W2034399770 cites W1671195947 @default.
- W2034399770 cites W1964764190 @default.
- W2034399770 cites W1965680643 @default.
- W2034399770 cites W1972300275 @default.
- W2034399770 cites W1972331061 @default.
- W2034399770 cites W1974768727 @default.
- W2034399770 cites W1983671931 @default.
- W2034399770 cites W1984274933 @default.
- W2034399770 cites W1988608065 @default.
- W2034399770 cites W1994532304 @default.
- W2034399770 cites W2007028022 @default.
- W2034399770 cites W2007639993 @default.
- W2034399770 cites W2011377018 @default.
- W2034399770 cites W2014611196 @default.
- W2034399770 cites W2014983646 @default.
- W2034399770 cites W2024699205 @default.
- W2034399770 cites W2025615074 @default.
- W2034399770 cites W2025851253 @default.
- W2034399770 cites W2028318125 @default.
- W2034399770 cites W2029650318 @default.
- W2034399770 cites W2030604587 @default.
- W2034399770 cites W2031340527 @default.
- W2034399770 cites W2031358406 @default.
- W2034399770 cites W2032584098 @default.
- W2034399770 cites W2034996626 @default.
- W2034399770 cites W2035105295 @default.
- W2034399770 cites W2041400374 @default.
- W2034399770 cites W2045000363 @default.
- W2034399770 cites W2045220147 @default.
- W2034399770 cites W2051695714 @default.
- W2034399770 cites W2056890828 @default.
- W2034399770 cites W2056945757 @default.
- W2034399770 cites W2061432777 @default.
- W2034399770 cites W2065179139 @default.
- W2034399770 cites W2066524134 @default.
- W2034399770 cites W2069466168 @default.
- W2034399770 cites W2070309516 @default.
- W2034399770 cites W2073898372 @default.
- W2034399770 cites W2075171646 @default.
- W2034399770 cites W2075965099 @default.
- W2034399770 cites W2077175094 @default.
- W2034399770 cites W2080327002 @default.
- W2034399770 cites W2080807893 @default.
- W2034399770 cites W2082033210 @default.
- W2034399770 cites W2082385277 @default.
- W2034399770 cites W2085265892 @default.
- W2034399770 cites W2085412371 @default.
- W2034399770 cites W2085777866 @default.
- W2034399770 cites W2088243322 @default.
- W2034399770 cites W2088757776 @default.
- W2034399770 cites W2090240281 @default.
- W2034399770 cites W2092447350 @default.
- W2034399770 cites W2096987374 @default.
- W2034399770 cites W2097174115 @default.
- W2034399770 cites W2103532601 @default.
- W2034399770 cites W2106145390 @default.
- W2034399770 cites W2112093320 @default.
- W2034399770 cites W2120246830 @default.
- W2034399770 cites W2126371427 @default.
- W2034399770 cites W2134823370 @default.
- W2034399770 cites W2134940342 @default.
- W2034399770 cites W2136278403 @default.
- W2034399770 cites W2141367881 @default.
- W2034399770 cites W2146074826 @default.
- W2034399770 cites W2149239890 @default.
- W2034399770 cites W2149744296 @default.
- W2034399770 cites W2150737519 @default.
- W2034399770 cites W2154816208 @default.
- W2034399770 cites W2158329246 @default.
- W2034399770 cites W2162287937 @default.
- W2034399770 cites W2169893340 @default.
- W2034399770 cites W2207378606 @default.
- W2034399770 doi "https://doi.org/10.1016/j.virol.2014.06.035" @default.
- W2034399770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4157101" @default.
- W2034399770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25063885" @default.
- W2034399770 hasPublicationYear "2014" @default.
- W2034399770 type Work @default.
- W2034399770 sameAs 2034399770 @default.
- W2034399770 citedByCount "29" @default.
- W2034399770 countsByYear W20343997702014 @default.
- W2034399770 countsByYear W20343997702015 @default.
- W2034399770 countsByYear W20343997702016 @default.
- W2034399770 countsByYear W20343997702017 @default.
- W2034399770 countsByYear W20343997702018 @default.
- W2034399770 countsByYear W20343997702019 @default.
- W2034399770 countsByYear W20343997702020 @default.
- W2034399770 countsByYear W20343997702021 @default.
- W2034399770 countsByYear W20343997702022 @default.