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• W2034400594 abstract "Several low fidelity DNA polymerases participate in generating mutations in immunoglobulin genes. Polymerase η is clearly involved in the process by causing substitutions of A:T base pairs, whereas polymerase ι has a controversial role. Although the frequency of mutations was decreased in the BL2 cell line deficient for polymerase ι, hypermutation was normal in the 129 strain of mice, which has a natural nonsense mutation in the Poli gene. It is possible that the mice compensated for the defect over time, or that polymerase η substituted in the absence of polymerase ι. To examine polymerase ι in a genetically defined background, we backcrossed the 129 nonsense mutation to the C57BL/6 strain for six generations. Class switch recombination and hypermutation were studied in these mice and in congenic mice doubly deficient for both polymerases ι and η. The absence of both polymerases did not affect production of IgG1, indicating that these enzymes are not involved in switch recombination. Poli−/−F6 mice had the same types of nucleotide substitutions in variable genes as their C57BL/6 counterparts, and mice doubly deficient for polymerases ι and η had the same mutational spectrum as Polh−/− mice. Thus, polymerase ι did not contribute to the mutational spectra, even in the absence of polymerase η." @default.
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• W2034400594 date "2006-03-01" @default.
• W2034400594 modified "2023-10-17" @default.
• W2034400594 title "Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase ι" @default.
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• W2034400594 doi "https://doi.org/10.1016/j.dnarep.2005.12.006" @default.
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