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- W2034402129 abstract "Toxic epidermal necrolysis (TEN) is a rare and devastating side effect of medication use characterized by epidermal apoptosis associated with massive epidermal dissociation over >30% total body surface area; fever; bullae; and generalized rash. This reaction often initially presents itself in the form of oral facial rashes and erosions. It is regularly misdiagnosed as its less extensive forms of Pemphighoid conditions, Erythema Multiforme and Stevens Johnson’s Syndrome. These early signs are initially seen by the primary care physicians and dental care providers, more specifically oral and maxillofacial surgeons. Incidence of TEN is low, and presentation of the disease is rapid and distinguishable. The first treatment staple for TEN involves immediate cessation of the offending drug; however, this is complicated by the prevalence with which TEN-causing drugs are prescribed. Among others, onset of TEN is associated with NSAIDs; sulfonamides; cephalosporins; aromatic anticonvulsants; and allopurinol, making early identification difficult. Furthermore, duration of TEN is associated with medication clearance, which can complicate treatment when TEN is caused by drugs with long half-lives. In this report, 2 cases are described in which the early recognition and cessation of medication therapy could have prevented both patients’ deaths secondary to the development of extensive TEN complicated by Gram-negative sepsis." @default.
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- W2034402129 date "2013-06-01" @default.
- W2034402129 modified "2023-09-25" @default.
- W2034402129 title "Early recognition and prevention of TEN: a cautionary report of 2 cases and literature review" @default.
- W2034402129 doi "https://doi.org/10.1016/j.oooo.2013.01.036" @default.
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