FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034402236> ?p ?o ?g. }

• W2034402236 endingPage "686" @default.
• W2034402236 startingPage "675" @default.
• W2034402236 abstract "Organophosphate (OP) insecticide resistance in certain strains of Musca domestica is associated with reduction in the carboxylesterase activity of a particular esterase isozyme. This has been attributed to a 'mutant ali-esterase hypothesis', which invokes a structural mutation to an ali-esterase resulting in the loss of its carboxylesterase activity but acquisition of OP hydrolase activity. It has been shown that the mutation in Lucilia cuprina is a Gly137-->Asp substitution in the active site of an esterase encoded by the Lc alpha E7 gene (Newcomb, R.D., Campbell, P.M., Ollis, D.L., Cheah, E., Russell, R.J., Oakeshott, J.G., 1997. A single amino acid substitution converts a carboxylesterase to an organophosphate hydrolase and confers insecticide resistance on a blowfly. Proc. Natl. Acad. Sci. USA 94, 7464-7468). We now report the cloning and characterisation of the orthologous M. domestica Md alpha E7 gene, including the sequencing of cDNAs from the OP resistant Rutgers and OP susceptible sbo and WHO strains. The Md alpha E7 gene has the same intron structure as Lc alpha E7 and encodes a protein with 76% amino acid identity to Lc alpha E7. Comparisons between susceptible and resistance alleles show resistance in M. domestica is associated with the same Gly137-->Asp mutation as in L. cuprina. Bacterial expression of the Rutgers allele shows its product has OP hydrolase activity. The data indicate identical catalytic mechanisms have evolved in orthologous Md alpha E7 and Lc alpha E7 molecules to endow diazinon-type resistance on the two species of higher Diptera." @default.
• W2034402236 created "2016-06-24" @default.
• W2034402236 creator A5039699593 @default.
• W2034402236 creator A5060590546 @default.
• W2034402236 creator A5062016987 @default.
• W2034402236 date "1999-08-01" @default.
• W2034402236 modified "2023-10-16" @default.
• W2034402236 title "The same amino acid substitution in orthologous esterases confers organophosphate resistance on the house fly and a blowfly" @default.
• W2034402236 cites W103861673 @default.
• W2034402236 cites W1602736810 @default.
• W2034402236 cites W1627243227 @default.
• W2034402236 cites W1898421433 @default.
• W2034402236 cites W1970087350 @default.
• W2034402236 cites W1974973563 @default.
• W2034402236 cites W1978663343 @default.
• W2034402236 cites W1981128382 @default.
• W2034402236 cites W2000595930 @default.
• W2034402236 cites W2003411267 @default.
• W2034402236 cites W2004627331 @default.
• W2034402236 cites W2009310436 @default.
• W2034402236 cites W2011754736 @default.
• W2034402236 cites W2026472543 @default.
• W2034402236 cites W2026524082 @default.
• W2034402236 cites W2037244859 @default.
• W2034402236 cites W2039781417 @default.
• W2034402236 cites W2044398541 @default.
• W2034402236 cites W2049489115 @default.
• W2034402236 cites W2059444819 @default.
• W2034402236 cites W2064517020 @default.
• W2034402236 cites W2066361830 @default.
• W2034402236 cites W2071595447 @default.
• W2034402236 cites W2077716622 @default.
• W2034402236 cites W2080682913 @default.
• W2034402236 cites W2082957343 @default.
• W2034402236 cites W2085188706 @default.
• W2034402236 cites W2085958374 @default.
• W2034402236 cites W2086427050 @default.
• W2034402236 cites W2092027429 @default.
• W2034402236 cites W2100837269 @default.
• W2034402236 cites W2118913377 @default.
• W2034402236 cites W2142994951 @default.
• W2034402236 cites W2150440892 @default.
• W2034402236 cites W2164320858 @default.
• W2034402236 cites W2167988140 @default.
• W2034402236 cites W2312944949 @default.
• W2034402236 cites W2320156887 @default.
• W2034402236 cites W2414307244 @default.
• W2034402236 cites W2989763588 @default.
• W2034402236 cites W3043423212 @default.
• W2034402236 cites W4293247451 @default.
• W2034402236 doi "https://doi.org/10.1016/s0965-1748(99)00035-1" @default.
• W2034402236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10451921" @default.
• W2034402236 hasPublicationYear "1999" @default.
• W2034402236 type Work @default.
• W2034402236 sameAs 2034402236 @default.
• W2034402236 citedByCount "173" @default.
• W2034402236 countsByYear W20344022362012 @default.
• W2034402236 countsByYear W20344022362013 @default.
• W2034402236 countsByYear W20344022362014 @default.
• W2034402236 countsByYear W20344022362015 @default.
• W2034402236 countsByYear W20344022362016 @default.
• W2034402236 countsByYear W20344022362017 @default.
• W2034402236 countsByYear W20344022362018 @default.
• W2034402236 countsByYear W20344022362019 @default.
• W2034402236 countsByYear W20344022362020 @default.
• W2034402236 countsByYear W20344022362021 @default.
• W2034402236 countsByYear W20344022362023 @default.
• W2034402236 crossrefType "journal-article" @default.
• W2034402236 hasAuthorship W2034402236A5039699593 @default.
• W2034402236 hasAuthorship W2034402236A5060590546 @default.
• W2034402236 hasAuthorship W2034402236A5062016987 @default.
• W2034402236 hasConcept C104317684 @default.
• W2034402236 hasConcept C119795356 @default.
• W2034402236 hasConcept C143065580 @default.
• W2034402236 hasConcept C153911025 @default.
• W2034402236 hasConcept C161176658 @default.
• W2034402236 hasConcept C173758957 @default.
• W2034402236 hasConcept C181199279 @default.
• W2034402236 hasConcept C2776414213 @default.
• W2034402236 hasConcept C2776588719 @default.
• W2034402236 hasConcept C2777261171 @default.
• W2034402236 hasConcept C2778207175 @default.
• W2034402236 hasConcept C2778325069 @default.
• W2034402236 hasConcept C2778549964 @default.
• W2034402236 hasConcept C2780120296 @default.
• W2034402236 hasConcept C2780900081 @default.
• W2034402236 hasConcept C501734568 @default.
• W2034402236 hasConcept C515207424 @default.
• W2034402236 hasConcept C54355233 @default.
• W2034402236 hasConcept C55493867 @default.
• W2034402236 hasConcept C59822182 @default.
• W2034402236 hasConcept C6557445 @default.
• W2034402236 hasConcept C86803240 @default.
• W2034402236 hasConceptScore W2034402236C104317684 @default.
• W2034402236 hasConceptScore W2034402236C119795356 @default.
• W2034402236 hasConceptScore W2034402236C143065580 @default.
• W2034402236 hasConceptScore W2034402236C153911025 @default.
• W2034402236 hasConceptScore W2034402236C161176658 @default.

• next