FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034404182> ?p ?o ?g. }

• W2034404182 endingPage "521" @default.
• W2034404182 startingPage "516" @default.
• W2034404182 abstract "✓ Calcitonin gene—related peptide (CGRP) is a potent vasodilator and a primary signaling molecule in neurovascular communication. In the present study, the authors examined cerebrovascular responses to CGRP and its related second messenger systems during cerebral vasospasm induced by subarachnoid hemorrhage (SAH). Tension measurements were performed in vitro on ring strips of basilar arteries obtained from rabbits subjected to artificial SAH and from control (non-SAH) animals. In vessels from SAH animals, which were preconstricted with serotonin, the vasorelaxant response to CGRP was attenuated. Because it has been suggested that vasodilation elicited by CGRP is mediated by cyclic 3′,5′-adenosine monophosphate (cAMP) and/or cyclic 3′,5′-guanosine monophosphate (cGMP), the vascular effects of directly activating these second messenger systems were also examined. The relaxant effect of forskolin, which activates adenylate cyclase directly, was slightly enhanced after SAH. In contrast, the relaxant effect of nitroglycerin (GTN), which activates soluble guanylate cyclase directly, was unchanged after SAH. The attenuation of CGRP-induced vasorelaxation could be the result of a modification in its ability to stimulate the production of second messengers. Experiments testing the capacity of CGRP to elevate cAMP levels showed no significant differences between vessels from non-SAH and SAH animals. Similarly, the resting levels of cAMP and the forskolin-induced elevations of cAMP did not differ between non-SAH and SAH animals. In contrast, cGMP levels were lower in resting and CGRP-treated vessels from SAH animals than in those from non-SAH animals. No significant differences in the levels of cGMP were observed between non-SAH and SAH vessels treated with GTN. This study indicates that CGRP-induced vasodilation is attenuated during vasospasm in a rabbit model of SAH. The findings also demonstrate that vasodilatory responses mediated by cAMP and cGMP are intact, although the levels of cGMP in SAH vessels are reduced. Together, these observations suggest that an attenuation in the capacity of vessels to dilate in response to CGRP occurs during cerebral vasospasm, and this change in CGRP vasoactivity is a result of modifications prior to, or independent of, the elevation of cyclic nucleotide second messengers." @default.
• W2034404182 created "2016-06-24" @default.
• W2034404182 creator A5000752378 @default.
• W2034404182 creator A5017640451 @default.
• W2034404182 creator A5058413004 @default.
• W2034404182 creator A5078044974 @default.
• W2034404182 creator A5066704593 @default.
• W2034404182 date "1995-09-01" @default.
• W2034404182 modified "2023-09-23" @default.
• W2034404182 title "Effects of subarachnoid hemorrhage on vascular responses to calcitonin gene—related peptide and its related second messengers" @default.
• W2034404182 cites W1973758743 @default.
• W2034404182 cites W1982206230 @default.
• W2034404182 cites W1983253016 @default.
• W2034404182 cites W1993084663 @default.
• W2034404182 cites W1994401085 @default.
• W2034404182 cites W1996290875 @default.
• W2034404182 cites W2012963479 @default.
• W2034404182 cites W2016299086 @default.
• W2034404182 cites W2019838609 @default.
• W2034404182 cites W2036134790 @default.
• W2034404182 cites W2039523986 @default.
• W2034404182 cites W2052385273 @default.
• W2034404182 cites W2054480215 @default.
• W2034404182 cites W2057367305 @default.
• W2034404182 cites W2072214628 @default.
• W2034404182 cites W2076176244 @default.
• W2034404182 cites W2080988519 @default.
• W2034404182 cites W2106780693 @default.
• W2034404182 cites W2129132447 @default.
• W2034404182 cites W2139805099 @default.
• W2034404182 cites W2155615934 @default.
• W2034404182 cites W2162356847 @default.
• W2034404182 cites W4293247451 @default.
• W2034404182 doi "https://doi.org/10.3171/jns.1995.83.3.0516" @default.
• W2034404182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7666231" @default.
• W2034404182 hasPublicationYear "1995" @default.
• W2034404182 type Work @default.
• W2034404182 sameAs 2034404182 @default.
• W2034404182 citedByCount "18" @default.
• W2034404182 countsByYear W20344041822017 @default.
• W2034404182 crossrefType "journal-article" @default.
• W2034404182 hasAuthorship W2034404182A5000752378 @default.
• W2034404182 hasAuthorship W2034404182A5017640451 @default.
• W2034404182 hasAuthorship W2034404182A5058413004 @default.
• W2034404182 hasAuthorship W2034404182A5066704593 @default.
• W2034404182 hasAuthorship W2034404182A5078044974 @default.
• W2034404182 hasConcept C118303440 @default.
• W2034404182 hasConcept C120770815 @default.
• W2034404182 hasConcept C126322002 @default.
• W2034404182 hasConcept C134018914 @default.
• W2034404182 hasConcept C163170386 @default.
• W2034404182 hasConcept C163235415 @default.
• W2034404182 hasConcept C170493617 @default.
• W2034404182 hasConcept C171614378 @default.
• W2034404182 hasConcept C2776668983 @default.
• W2034404182 hasConcept C2777736543 @default.
• W2034404182 hasConcept C2778827303 @default.
• W2034404182 hasConcept C2779276759 @default.
• W2034404182 hasConcept C2779627488 @default.
• W2034404182 hasConcept C2780994212 @default.
• W2034404182 hasConcept C2781012200 @default.
• W2034404182 hasConcept C3020139451 @default.
• W2034404182 hasConcept C519581460 @default.
• W2034404182 hasConcept C71924100 @default.
• W2034404182 hasConceptScore W2034404182C118303440 @default.
• W2034404182 hasConceptScore W2034404182C120770815 @default.
• W2034404182 hasConceptScore W2034404182C126322002 @default.
• W2034404182 hasConceptScore W2034404182C134018914 @default.
• W2034404182 hasConceptScore W2034404182C163170386 @default.
• W2034404182 hasConceptScore W2034404182C163235415 @default.
• W2034404182 hasConceptScore W2034404182C170493617 @default.
• W2034404182 hasConceptScore W2034404182C171614378 @default.
• W2034404182 hasConceptScore W2034404182C2776668983 @default.
• W2034404182 hasConceptScore W2034404182C2777736543 @default.
• W2034404182 hasConceptScore W2034404182C2778827303 @default.
• W2034404182 hasConceptScore W2034404182C2779276759 @default.
• W2034404182 hasConceptScore W2034404182C2779627488 @default.
• W2034404182 hasConceptScore W2034404182C2780994212 @default.
• W2034404182 hasConceptScore W2034404182C2781012200 @default.
• W2034404182 hasConceptScore W2034404182C3020139451 @default.
• W2034404182 hasConceptScore W2034404182C519581460 @default.
• W2034404182 hasConceptScore W2034404182C71924100 @default.
• W2034404182 hasIssue "3" @default.
• W2034404182 hasLocation W20344041821 @default.
• W2034404182 hasLocation W20344041822 @default.
• W2034404182 hasOpenAccess W2034404182 @default.
• W2034404182 hasPrimaryLocation W20344041821 @default.
• W2034404182 hasRelatedWork W1547687776 @default.
• W2034404182 hasRelatedWork W1943192612 @default.
• W2034404182 hasRelatedWork W1989210079 @default.
• W2034404182 hasRelatedWork W2003450342 @default.
• W2034404182 hasRelatedWork W2034404182 @default.
• W2034404182 hasRelatedWork W2070551626 @default.
• W2034404182 hasRelatedWork W2085871851 @default.
• W2034404182 hasRelatedWork W2100217732 @default.
• W2034404182 hasRelatedWork W3195977023 @default.
• W2034404182 hasRelatedWork W4232012187 @default.
• W2034404182 hasVolume "83" @default.

• next