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- W2034405425 abstract "Serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and norepinephrine (NE) concentrations in seven brain regions were compared in sexually refractory, physically active, and inactive male rats. Also examined were 5-HIAA/5-HT and DOPAC/DA concentration ratios. Sexually refractory males were permitted uninterrupted copulation with successive receptive females until they failed to mount or ejaculate in a set period. Physically active males ran in motor-driven activity wheels except during the postejaculatory refractory periods of experimental animals, and inactive males remained alone in testing arenas. Significant group differences were found only in monoamine concentrations in the medial preoptic area (MPOA) and the medial forebrain bundle (MFB). In the MPOA, 5-HT concentration was elevated in sexually refractory males, as was DA in both refractory and active animals. In the MFB, 5-HT concentration was increased in active males. MFB DOPAC levels of sexually refractory rats significantly correlated inversely with their ejaculation totals, as did MFB and dorsal raphe (DR) NE levels. The results suggest that the MPOA is a forebrain target for inhibitory influences on male rat sexual behavior of ascending serotonergic fibers and that increased MFB 5-HT and MPOA DA may be associated with general activity." @default.
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- W2034405425 date "1987-01-01" @default.
- W2034405425 modified "2023-09-23" @default.
- W2034405425 title "Sexual refractoriness and locomotion effects on brain monoamines in the male rat" @default.
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- W2034405425 doi "https://doi.org/10.1016/0031-9384(87)90312-x" @default.
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