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- W2034405462 abstract "The action of serotonin (5HT) was investigated on guinea-pig isolated ileum. Low concentrations of 5HT (10−8-2.5 × 10−7 mol · l−1) produced contractile responses which were abolished by atropine and by methionine enkephalin but not by methysergide. Higher concentrations of 5HT (5 × 10−7-5 × 10−6 mol · l−1) produced contractions which were inhibited by methysergide. The atropine-sensitive response was also abolished following desensitization of preparations to substance P and by the substance P antagonist [D-Pro2,D-Phe7,D-Trp9]SP. It was concluded that the atropine-sensitive response to 5HT is mediated by substance P." @default.
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- W2034405462 date "1983-02-01" @default.
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- W2034405462 title "Substance P mediates atropine-sensitive response of guinea-pig ileum to serotonin" @default.
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- W2034405462 doi "https://doi.org/10.1016/0014-2999(83)90090-0" @default.
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