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- W2034406282 abstract "The most recently published guidelines about the management of adult bronchiectasis suggest screening all patients for allergic bronchopulmonary aspergillosis (ABPA). However, in some cases, tests for ABPA might be altered but not consistent with a diagnosis of ABPA. No recommendations are available about management of these patients with only some nonspecific serological alterations suggestive of ABPA and about their risk to develop ABPA or other Aspergillus-associated syndromes. We reviewed our prospectively-collected cohort of consecutive adult patients with non-cystic fibrosis bronchiectasis screened for ABPA at baseline. Out of 385 patients the prevalence of ABPA was 4%. Almost one quarter (89, 23%) of our patients presented, at the time of first evaluation, one or more alterations of ABPA testing. 18 (20%) patients showed multiple contemporary alterations of screening exams. Out of 73 patients with nonspecific ABPA screening alterations at baseline and at least a 12-month clinical follow-up (median follow-up time 25 months), the majority (57 patients, 78%) showed neither clinical nor functional deterioration and none of them developed Aspergillus-associated syndromes, while a minority of patients (16 - 22%) repeated screening tests because of clinical and/or functional deterioration. In these patients the repetition of screening tests, together with functional and clinical evolution, allowed to make a diagnosis of ABPA in 1 case and severe asthma with fungal sensitisation (SAFS) in 5 cases. In conclusion, a non-negligible proportion of patients with nonspecific alterations of screening tests at baseline may develop Aspergillus-associated syndromes during follow-up. Future studies are needed to confirm our observations." @default.
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- W2034406282 date "2004-08-01" @default.
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- W2034406282 title "Retinoblastoma in a child conceived by in vitro fertilisation" @default.
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- W2034406282 doi "https://doi.org/10.1136/bjo.2003.041160" @default.
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