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- W2034406299 abstract "This chapter describes ofloxacin, its general information, physical characteristics, analytical profiles, drug metabolism, and pharmacokinetics. Ofloxacin is a pale yellow or bright yellow crystalline powder, colorless needles from ethanol. The concentrate solution of the drug has a pH of 3.8–5.5 in aqueous. It is slightly soluble in water, alcohol, dichloromethane, and methyl alcohol but sparingly soluble in chloroform. The solubility of ofloxacin varies depending on pH. Ofloxacin tablets are stored below 30°C (86 °F) in a well-closed container. Ofloxacin injection in single-use vials and premixed bottles are stored at controlled room temperature (59–86 °F, 15–30 °C) and protected from freezing and light. Ofloxacin is a fluoroquinolone carboxylic acid antibacterial showing bactericidal effects by inhibition of DNA gyrase. This inhibition leads to promotion of double strand DNA breakage in susceptible organisms. Ofloxacin is given orally or intravenously as the base or hydrochloride form, respectively. Oral dose of ofloxacin is rapidly and well absorbed from the gastrointestinal tract and oral bioavailability is almost complete in health-fasting adults. Ofloxacin is metabolized in liver at the piperazinyl moiety following oral doses. Two metabolites of ofloxacin, desmethylofloxacin, and ofloxacin N-oxide are identified at low concentrations in human urine. Ofloxacin is excreted mainly (90%) unchanged by the kidney via active tubular secretion and glomerular filtration with an elimination half-life of 5–7.5 h." @default.
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- W2034406299 title "Stability indicating reversed-phase liquid chromatographic determination of ciprofloxacin as bulk drug and in pharmaceutical formulations" @default.
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- W2034406299 doi "https://doi.org/10.1016/s0731-7085(99)00298-8" @default.
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