Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034408332> ?p ?o ?g. }
- W2034408332 endingPage "470" @default.
- W2034408332 startingPage "458" @default.
- W2034408332 abstract "Our laboratory and others have shown that overexpression of Dlx5 stimulates osteoblast differentiation. Dlx5 −/− / Dlx6 −/− mice have more severe craniofacial and limb defects than Dlx5 −/− , some of which are potentially due to defects in osteoblast maturation. We wished to investigate the degree to which other Dlx genes compensate for the lack of Dlx5 , thus allowing normal development of the majority of skeletal elements in Dlx5 −/− mice. Dlx gene expression in cells from different stages of the osteoblast lineage isolated by FACS sorting showed that Dlx2 , Dlx5 and Dlx6 are expressed most strongly in less mature osteoblasts, whereas Dlx3 is very highly expressed in differentiated osteoblasts and osteocytes. In situ hybridization and Northern blot analysis demonstrated the presence of endogenous Dlx3 mRNA within osteoblasts and osteocytes. Dlx3 strongly upregulates osteoblastic markers with a potency comparable to Dlx5 . Cloned chick or mouse Dlx6 showed stimulatory effects on osteoblast differentiation. Our results suggest that Dlx2 and Dlx6 have the potential to stimulate osteoblastic differentiation and may compensate for the absence of Dlx5 to produce relatively normal osteoblastic differentiation in Dlx5 knockout mice, while Dlx3 may play a distinct role in late stage osteoblast differentiation and osteocyte function." @default.
- W2034408332 created "2016-06-24" @default.
- W2034408332 creator A5008131616 @default.
- W2034408332 creator A5015641857 @default.
- W2034408332 creator A5028002321 @default.
- W2034408332 creator A5032733793 @default.
- W2034408332 creator A5034936703 @default.
- W2034408332 creator A5043123166 @default.
- W2034408332 creator A5047640338 @default.
- W2034408332 creator A5057645458 @default.
- W2034408332 creator A5066842181 @default.
- W2034408332 creator A5085032833 @default.
- W2034408332 creator A5086923843 @default.
- W2034408332 creator A5090651758 @default.
- W2034408332 date "2008-04-01" @default.
- W2034408332 modified "2023-09-29" @default.
- W2034408332 title "Expression and function of Dlx genes in the osteoblast lineage" @default.
- W2034408332 cites W1509762695 @default.
- W2034408332 cites W1581170268 @default.
- W2034408332 cites W1964732161 @default.
- W2034408332 cites W1966554913 @default.
- W2034408332 cites W1981340011 @default.
- W2034408332 cites W1993310108 @default.
- W2034408332 cites W2008711375 @default.
- W2034408332 cites W2016091065 @default.
- W2034408332 cites W2023680421 @default.
- W2034408332 cites W2031111711 @default.
- W2034408332 cites W2032255653 @default.
- W2034408332 cites W2035377736 @default.
- W2034408332 cites W2044107874 @default.
- W2034408332 cites W2046491654 @default.
- W2034408332 cites W2053622020 @default.
- W2034408332 cites W2054367286 @default.
- W2034408332 cites W2055573396 @default.
- W2034408332 cites W2064624464 @default.
- W2034408332 cites W2067077186 @default.
- W2034408332 cites W2070270500 @default.
- W2034408332 cites W2071680116 @default.
- W2034408332 cites W2083490046 @default.
- W2034408332 cites W2084363118 @default.
- W2034408332 cites W2091527049 @default.
- W2034408332 cites W2096060803 @default.
- W2034408332 cites W2102945947 @default.
- W2034408332 cites W2104465349 @default.
- W2034408332 cites W2106730339 @default.
- W2034408332 cites W2108998830 @default.
- W2034408332 cites W2112659858 @default.
- W2034408332 cites W2114656857 @default.
- W2034408332 cites W2120162279 @default.
- W2034408332 cites W2135144225 @default.
- W2034408332 cites W2148339830 @default.
- W2034408332 cites W2155756637 @default.
- W2034408332 cites W2158001082 @default.
- W2034408332 cites W2168621238 @default.
- W2034408332 cites W2169482727 @default.
- W2034408332 cites W2170020907 @default.
- W2034408332 doi "https://doi.org/10.1016/j.ydbio.2008.01.001" @default.
- W2034408332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2679944" @default.
- W2034408332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18280462" @default.
- W2034408332 hasPublicationYear "2008" @default.
- W2034408332 type Work @default.
- W2034408332 sameAs 2034408332 @default.
- W2034408332 citedByCount "77" @default.
- W2034408332 countsByYear W20344083322012 @default.
- W2034408332 countsByYear W20344083322013 @default.
- W2034408332 countsByYear W20344083322014 @default.
- W2034408332 countsByYear W20344083322015 @default.
- W2034408332 countsByYear W20344083322016 @default.
- W2034408332 countsByYear W20344083322017 @default.
- W2034408332 countsByYear W20344083322018 @default.
- W2034408332 countsByYear W20344083322019 @default.
- W2034408332 countsByYear W20344083322020 @default.
- W2034408332 countsByYear W20344083322021 @default.
- W2034408332 countsByYear W20344083322022 @default.
- W2034408332 crossrefType "journal-article" @default.
- W2034408332 hasAuthorship W2034408332A5008131616 @default.
- W2034408332 hasAuthorship W2034408332A5015641857 @default.
- W2034408332 hasAuthorship W2034408332A5028002321 @default.
- W2034408332 hasAuthorship W2034408332A5032733793 @default.
- W2034408332 hasAuthorship W2034408332A5034936703 @default.
- W2034408332 hasAuthorship W2034408332A5043123166 @default.
- W2034408332 hasAuthorship W2034408332A5047640338 @default.
- W2034408332 hasAuthorship W2034408332A5057645458 @default.
- W2034408332 hasAuthorship W2034408332A5066842181 @default.
- W2034408332 hasAuthorship W2034408332A5085032833 @default.
- W2034408332 hasAuthorship W2034408332A5086923843 @default.
- W2034408332 hasAuthorship W2034408332A5090651758 @default.
- W2034408332 hasBestOaLocation W20344083322 @default.
- W2034408332 hasConcept C104317684 @default.
- W2034408332 hasConcept C117072055 @default.
- W2034408332 hasConcept C121587040 @default.
- W2034408332 hasConcept C134018914 @default.
- W2034408332 hasConcept C148738053 @default.
- W2034408332 hasConcept C150194340 @default.
- W2034408332 hasConcept C202751555 @default.
- W2034408332 hasConcept C2778260815 @default.
- W2034408332 hasConcept C2780973866 @default.
- W2034408332 hasConcept C54355233 @default.