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- W2034408855 abstract "Editorial1 July 1960IMMUNITY TO TISSUE GRAFTSPAUL W. CLOUGH, M.D.PAUL W. CLOUGH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-1-228 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has long been common knowledge that if skin is grafted on human subjects, only autografts, from the same individual, survive. Homografts, from other individuals of the same species, are rejected except when the donor and recipient are identical twins with exactly the same antigens. This has been found true of all vertebrates studied, from fish to monkeys.If some means could be found to circumvent this process of rejection of the graft, it would be a therapeutic triumph of major importance. It should make possible not merely homografts of skin but of tissues generally, including the transplantation of intact...1 Medawar PB: The immunology of transplantation, Harvey Lectures, Ser. 52, 1957, p. 144. Google Scholar2 Mitchison NA: Passive transfer of transplantation immunity, Proc. Roy. Soc., London s. B. 142: 72, 1954. Google Scholar3 BerrianBrent JHL: Cell bound antibodies in transplantation experiments, Ann. New York Acad. Sc. 73: 654-661, 1958. CrossrefMedlineGoogle Scholar4 Billingham RE: Reactions of grafts against their hosts, Science 130: 947-953, 1959. CrossrefMedlineGoogle Scholar5 BarnesFordIlberyLoutit DWCEPLJF: Tolerance in the radiation chimaera, Transplantation Bull. 5: 101-106, incorporated in Plast. and Reconstruct. Surg. 22, 1958. Google Scholar6 Hildemann WH: Specific modifications of the immune response, Transplantation Bull. 5: 97-101, incorporated in Plast. and Reconstruct. Surg. 22, 1958. Google Scholar7 FeltonKauffmanPrescottOttinger LDGBB: Studies on mechanism of immunologic paralysis induced in mice by pneumococcal polysaccharides, J. Immunol. 74: 17-26 and 205-213, 1955. MedlineGoogle Scholar8 CannonTerasakiLongmire JAPWP: Unexpected manifestations of induced tolerance in skin homografts in chicks, Ann. New York Acad. Sc. 73: 862-868, 1958. CrossrefMedlineGoogle Scholar9 EgdahlRollerSwansonVarco RHFRRLRS: Acquired tolerance to homografts and heterografts in the rat, Ann. New York Acad. Sc. 73: 842-847, 1958. CrossrefMedlineGoogle Scholar10 CannonTerasakiLongmire JAPWP: Study of factors influencing induced tolerance to skin homografts in the chicken, Ann. Surg. 146: 278-284, 1957. CrossrefMedlineGoogle Scholar11 Egdahl RH: Immunological maturation and defects in immunological capacity, Transplantation Bull. 5: 87-97, incorporated in Plast. and Reconstruct. Surg. 22, 1958. Google Scholar12 BaxterGoldsteinMcMillan HMAGC: The fate of human fetal homo- and heterografts, Transplantation Bull. 5: 516-524, incorporated in Plast. and Reconstruct. Surg. 22, 1958. Google Scholar13 Snyderman RK: Clinical application of embryonic skin grafts, Ann. New York Acad. Sc. 73: 561-563, 1958. CrossrefMedlineGoogle Scholar14 AshleySteinPetersonGrazerLongmire FLHRFLP: Tolerance induced by pooled antigen, Transplantation Bull. 5: 29-30, incorporated in Plast. and Reconstruct. Surg. 22, 1958. CrossrefGoogle Scholar15 PeesaGombos AA: Acquired tolerance of skin homografts in dogs, Transplantation Bull. 5: 30-32, incorporated in Plast. and Reconstruct. Surg. 22, 1958. Google Scholar16 Trentin JJ: Tolerance and homologous disease in irradiated mice protected with homologous bone marrow, Ann. New York Acad. Sc. 73: 799, 1958. CrossrefMedlineGoogle Scholar17 ThomasAshleyLochteJaretzskiSahlerFerrebee EDCAHLAODJW: Homografts of bone marrow in dogs after lethal total body radiation, Blood 14: 720-736, 1959. CrossrefMedlineGoogle Scholar18 MannickLochteAshleyThomasFerrebee JAHLCAEDJW: Autografts of bone marrow in dogs after lethal total-body radiation, Blood 15: 255-266, 1960. CrossrefMedlineGoogle Scholar19 RothbergBlairGomezMcNulty HEBACW: Observations on chimpanzees after whole body radiation and homologous bone marrow treatment, Blood 14: 1302-1321, 1959. CrossrefMedlineGoogle Scholar20 ThomasLochteFerrebee EDHLJW: Irradiation of the entire body and marrow transplantation: some observations and comments, Blood 14: 1-23, 1959. CrossrefMedlineGoogle Scholar21 AtkinsonMahoneySchwartzHesch JBFJIRJA: Therapy of acute leukemia by whole body irradiation and bone marrow transplantation from an identical twin, Blood 14: 228-234, 1959. CrossrefMedlineGoogle Scholar22 Thomas ED: Discussion, Bone Marrow Transplantation Conference, Atlantic City, N. J., April 13, 1959, Blood 14: 1254-1256, 1959. Google Scholar23 Favour CB: Comparative immunology and phylogeny of homotransplantation, Ann. New York Acad. Sc. 73: 590-595, 1958. CrossrefMedlineGoogle Scholar24 Dempster WJ: Kidney homotransplantation, Brit. J. Surg. 40: 447-465, 1952-53. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1960Volume 53, Issue 1Page: 228-236KeywordsAntigensHomograftsImmunityMonozygotic twinsTransplantation Issue Published: 1 July 1960 PDF DownloadLoading ..." @default.
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