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• W2034422938 endingPage "568" @default.
• W2034422938 startingPage "559" @default.
• W2034422938 abstract "Surgical correction of congenital heart defects often requires the use of valves, patches, or conduits to establish anatomic continuity. Homografts, xenografts, or mechanical prosthetic devices are frequently implanted during these surgical procedures. These grafts however lack growth potential, are associated with increased risk of thrombosis and infection and have limited durability, thus increasing the morbidity and mortality of their application in pediatric cardiac surgery. These limitations are being addressed through the development of living, biologic tissue-engineered valves, patches, and conduits. Pilot studies and phase 1 clinical trials are currently underway to evaluate their feasibility, safety, and efficacy. The optimal scaffold, cell source, and conditioning parameters, however, still remain to be determined and are areas of active research." @default.
• W2034422938 created "2016-06-24" @default.
• W2034422938 creator A5015733578 @default.
• W2034422938 creator A5033491632 @default.
• W2034422938 date "2008-05-01" @default.
• W2034422938 modified "2023-09-26" @default.
• W2034422938 title "The Development of Tissue-Engineered Grafts for Reconstructive Cardiothoracic Surgical Applications" @default.
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• W2034422938 doi "https://doi.org/10.1203/01.pdr.0000305938.92695.b9" @default.
• W2034422938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18427302" @default.
• W2034422938 hasPublicationYear "2008" @default.
• W2034422938 type Work @default.

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