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- W2034437587 abstract "hHensiv(; ( :hemotherapy [)ro(h](:es (:omplete remiss ions in a high prol)ortioll of subjects with acute lymphoblast i ( : leukemia (ALl,) and acute mvelobhlsli(: leukemia (AML) I1,2 I. However. many of these pat ients u l t imate ly relapse. Complete remiss ions are cons iderab ly less comm(m fol lowing ( :hemotherapy for (:hroni(: mye logenous leukemia (CML). chronic lyml)hO(:yti(: leukemia (CLL), and hairy (:ell leukemia ([ICL). Nevertheless, those a(:hieving comple te remiss ions with innowi t ive therat)ies like bone marrow t ransp lan ta t ion , biologi(: ~.|g, e l l tS like interferon, or drugs that mo(lifv l )yr imidine meta[)olism, often relapse I3-6]. Thus , leukemia re(:urre, tl(:e is a major prol)lem even after suc(:essful inilia] t reatment t)f leukemia. Most data suggest that relat)ses arise from residual leukemia (:ells su rv iv ing init ial t reatment . These (:ells are referred to as min ima l residual leukemia {MRI,). The disl)arity be tween the (:lini(:al def in i t ion of (:omt)lete remissi(m imd the t)resem:e of residual leukemia (:ells results from the inabi l i ty to (tete(:t small number s of leukemia (:ells. Because (tete(:ting mi n i ma l residual leuke, mi;i might have iml)()rtanl I)i()logi(: and c:linic:al impli t :at ions, there is (:onsi(tera[)le interest in ( leveloping m()re sensi t ive dete(:tion te(:hni(:s, t lere, we review data regar(linM MR1, and (tis(:uss its (:lini(:,l and bioh)gi<al iml)li(:ations." @default.
- W2034437587 created "2016-06-24" @default.
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- W2034437587 date "1991-03-01" @default.
- W2034437587 modified "2023-10-14" @default.
- W2034437587 title "Detecting minimal residual leukemia" @default.
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- W2034437587 doi "https://doi.org/10.1016/0165-4608(91)90049-z" @default.
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