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- W2034443606 abstract "Epigenetic mechanisms such as methylation of DNA, could lead to abnormal neurodevelopment and may be important in the etiology of schizophrenia. Maternal dietary folate intake may play a role in determining methylation levels. The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for methylation. We carried out a meta-analysis of MTHFR C677T genotype and schizophrenia risk, and found that TT homozygotes had a significantly increased risk, OR 1.48 (1.18-1.86). This supports the hypothesis that folate status is a determinant of schizophrenia risk. Larger studies of this issue are required, together with studies of maternal genotype which could identify whether maternal folate status during pregnancy is important." @default.
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- W2034443606 date "2005-01-01" @default.
- W2034443606 modified "2023-10-14" @default.
- W2034443606 title "A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk" @default.
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- W2034443606 doi "https://doi.org/10.1002/ajmg.b.30170" @default.
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