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• W2034450471 endingPage "C1033" @default.
• W2034450471 startingPage "C1021" @default.
• W2034450471 abstract "Clinical trials of bone marrow mesenchymal stem cell (MSC) therapy have thus far demonstrated moderate and inconsistent benefits, indicating an urgent need to improve therapeutic efficacy. Although administration of sufficient cells is necessary to achieve maximal therapeutic benefits, documented MSC clinical trials have largely relied on injections of ∼1 × 10 6 cells/kg, which appears too low to elicit a robust therapeutic response according to published preclinical studies. However, repeated cell passaging necessary for large-scale expansion of MSC causes cellular senescence and reduces stem cell potency. Using the RNA mimetic polyinosinic-polycytidylic acid [poly(I:C)] to engage MSC Toll-like receptor 3 (TLR3), we found that poly(I:C), signaling through multiple mitogen-activated protein kinase pathways, induced therapeutically relevant trophic factors such as interleukin-6-type cytokines, stromal-derived factor 1, hepatocyte growth factor, and vascular endothelial growth factor while slightly inhibiting the proliferation and migration potentials of MSC. At the suboptimal injection dose of 1 × 10 6 cells/kg, poly(I:C)-treated MSC, but not untreated MSC, effectively stimulated regeneration of the failing hamster heart 1 mo after cell administration. The regenerating heart exhibited increased CD34 + /Ki67 + and CD34 + /GATA4 + progenitor cells in the presence of decreased inflammatory cells and cytokines. Cardiac functional improvement was associated with a ∼50% reduction in fibrosis, a ∼40% reduction in apoptosis, and a ∼55% increase in angiogenesis, culminating in prominent cardiomyogenesis evidenced by abundant distribution of small myocytes and a ∼90% increase in wall thickening. These functional, histological, and molecular characterizations thus establish the utility of TLR3 engagement for enabling the low-dose MSC therapy that may be translated to more efficacious clinical applications." @default.
• W2034450471 created "2016-06-24" @default.
• W2034450471 creator A5005020520 @default.
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• W2034450471 date "2012-11-15" @default.
• W2034450471 modified "2023-09-27" @default.
• W2034450471 title "Activation of Toll-like receptor 3 amplifies mesenchymal stem cell trophic factors and enhances therapeutic potency" @default.
• W2034450471 cites W1495769178 @default.
• W2034450471 cites W164587771 @default.
• W2034450471 cites W1804670053 @default.
• W2034450471 cites W1907871334 @default.
• W2034450471 cites W1963756072 @default.
• W2034450471 cites W1969866392 @default.
• W2034450471 cites W1971858639 @default.
• W2034450471 cites W1972094098 @default.
• W2034450471 cites W1972392301 @default.
• W2034450471 cites W1977935404 @default.
• W2034450471 cites W1979406644 @default.
• W2034450471 cites W1980498532 @default.
• W2034450471 cites W1983838712 @default.
• W2034450471 cites W1984007061 @default.
• W2034450471 cites W1985292788 @default.
• W2034450471 cites W1988822862 @default.
• W2034450471 cites W1994446230 @default.
• W2034450471 cites W1994524954 @default.
• W2034450471 cites W1998211335 @default.
• W2034450471 cites W1998461585 @default.
• W2034450471 cites W2002073421 @default.
• W2034450471 cites W2003996125 @default.
• W2034450471 cites W2005349078 @default.
• W2034450471 cites W2010193429 @default.
• W2034450471 cites W2015499802 @default.
• W2034450471 cites W2018258390 @default.
• W2034450471 cites W2023200943 @default.
• W2034450471 cites W2023829709 @default.
• W2034450471 cites W2026429155 @default.
• W2034450471 cites W2037688699 @default.
• W2034450471 cites W2048354593 @default.
• W2034450471 cites W2049226446 @default.
• W2034450471 cites W2049446122 @default.
• W2034450471 cites W2051740472 @default.
• W2034450471 cites W2053861675 @default.
• W2034450471 cites W2060437379 @default.
• W2034450471 cites W2060837796 @default.
• W2034450471 cites W2063456851 @default.
• W2034450471 cites W2064839261 @default.
• W2034450471 cites W2065623221 @default.
• W2034450471 cites W2073024911 @default.
• W2034450471 cites W2076348072 @default.
• W2034450471 cites W2076361525 @default.
• W2034450471 cites W2076491580 @default.
• W2034450471 cites W2077084901 @default.
• W2034450471 cites W2081066133 @default.
• W2034450471 cites W2085604801 @default.
• W2034450471 cites W2086348217 @default.
• W2034450471 cites W2097675424 @default.
• W2034450471 cites W2101737958 @default.
• W2034450471 cites W2103488083 @default.
• W2034450471 cites W2107065228 @default.
• W2034450471 cites W2108896478 @default.
• W2034450471 cites W2111004371 @default.
• W2034450471 cites W2114764321 @default.
• W2034450471 cites W2114959629 @default.
• W2034450471 cites W2115185894 @default.
• W2034450471 cites W2117267805 @default.
• W2034450471 cites W2117855475 @default.
• W2034450471 cites W2118896182 @default.
• W2034450471 cites W2121678953 @default.
• W2034450471 cites W2122059149 @default.
• W2034450471 cites W2123220532 @default.
• W2034450471 cites W2124090816 @default.
• W2034450471 cites W2124396531 @default.
• W2034450471 cites W2124778856 @default.
• W2034450471 cites W2126957024 @default.
• W2034450471 cites W2127727542 @default.
• W2034450471 cites W2130794824 @default.
• W2034450471 cites W2131448844 @default.
• W2034450471 cites W2132124040 @default.
• W2034450471 cites W2133375451 @default.
• W2034450471 cites W2135932320 @default.
• W2034450471 cites W2136016143 @default.
• W2034450471 cites W2136078305 @default.
• W2034450471 cites W2138732093 @default.
• W2034450471 cites W2139471245 @default.
• W2034450471 cites W2140413558 @default.
• W2034450471 cites W2143742274 @default.
• W2034450471 cites W2147687016 @default.
• W2034450471 cites W2147691664 @default.
• W2034450471 cites W2147966579 @default.
• W2034450471 cites W2155937459 @default.
• W2034450471 cites W2156969855 @default.
• W2034450471 cites W2157742358 @default.
• W2034450471 cites W2162670161 @default.

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