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• W2034451415 abstract "We investigated the effects of intracerebroventricular (ICV) injection of orexin-A on plasma corticosterone (CORT) concentration and brain monoamine metabolism to clarify the mechanism by which ICV orexin-A induced arousal in chicks. In Experiment 1, plasma CORT concentrations were measured as an indicator of hypothalamic-pituitary-adrenal (HPA) axis activity. There was no significant difference in CORT concentration between the control and orexin-A administered groups. In Experiment 2, the concentrations of monoamines (norepinephrine, dopamine and serotonin), their metabolites, and their metabolic turnover rates in the telencephalon, mesencephalon, and diencephalon were investigated. All metabolic turnover rates studied were increased at all brain sites after ICV orexin-A injection. In conclusion, the HPA axis does not appear to be involved in arousal-inducing mechanisms of orexin-A in neonatal chicks; however, several monoaminergic systems do." @default.
• W2034451415 created "2016-06-24" @default.
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• W2034451415 date "2010-10-01" @default.
• W2034451415 modified "2023-09-25" @default.
• W2034451415 title "Intracerebroventricular injection of orexin-A stimulates monoamine metabolism but not HPA axis in neonatal chicks" @default.
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• W2034451415 doi "https://doi.org/10.1016/j.neulet.2010.08.043" @default.
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