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- W2034453888 abstract "Chronic opioid administration modulates lymphocytes’ functional capabilities increasing susceptibility to infectious diseases. Bacille-Calmette-Guérin (BCG) vaccination initiates a non-specific and specific cell-mediated immunity orchestrated by T lymphocytes including γδ T lymphocytes. γδ T lymphocytes increase in natural killer and antigen-directed cytolytic response following BCG vaccination. The objective of this study was to determine morphine effects on γδ T lymphocytes’ cytolytic activity. Pigs were chronically administered morphine and subsequently vaccinated with Mycobacterium bovis BCG. By administering morphine prior to BCG vaccination, natural killer response was significantly suppressed (p = .034). Furthermore, innate cytolytic response against M. bovis-infected monocytes (p = .002) as well as antigen specific cytolytic functions (p = .04) were significantly altered due to morphine administration. It was concluded that administering morphine prior to BCG vaccination significantly altered γδ T lymphocyte cytolytic responses." @default.
- W2034453888 created "2016-06-24" @default.
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- W2034453888 date "2007-02-01" @default.
- W2034453888 modified "2023-10-18" @default.
- W2034453888 title "Morphine modulates γδ lymphocytes cytolytic activity following BCG vaccination" @default.
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- W2034453888 doi "https://doi.org/10.1016/j.bbi.2006.06.003" @default.
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