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- W2034454024 abstract "High-dose interleukin-2 (IL-2), given via continuous intravenous (i.v.) infusion, induces lymphokine-activated killer (LAK) cell cytotoxicity against tumor cells. These LAKs exhibit enhanced cytotoxicity against tumor cells in vitro when they are subsequently pulsed with additional IL-2. Famotidine may increase LAK cytotoxicity against neoplastic cells by allowing for greater IL-2 uptake at the IL-2 receptor on lymphocytes. Twenty-three (23) patients received famotidine 20 mg i.v. twice per day and continuous-infusion IL-2 (18 MIU/m2/24 hours) for 72 hours, followed by a 24-hour rest, then 1–3 daily-pulse IL-2 doses of 18 MIU/m2 over 15–30 minutes preceded by famotidine 20 mg i.v. Cycles were repeated every 3 weeks. The most common metastatic sites were lung, lymph node, and subcutaneous/soft tissue. The most common toxicities were fever, rigor, nausea/emesis, hypophosphatemia, hypotension, elevated creatinine, and pulmonary edema. There were no treatment-related deaths. One (1) complete (4%) and 9 partial responses (39%) were seen (43% total response rate; 95% confidence interval: 22%–65%). Median survival for all patients is 13 months. The combination of famotidine and high-dose continuous infusion + pulse IL-2 is active in metastatic melanoma." @default.
- W2034454024 created "2016-06-24" @default.
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- W2034454024 date "2009-02-01" @default.
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- W2034454024 title "Activity of Continuous Infusion + Pulse Interleukin-2 with Famotidine in Metastatic Melanoma" @default.
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- W2034454024 doi "https://doi.org/10.1089/cbr.2008.0540" @default.
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