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- W2034454838 abstract "Heparin consists of a series of fractions of different molecular weight. Whilst low MW fractions exert a strong anti Xa-activity, high MW fractions mainly enhance thrombin inhibition. A semi-synthetic polysulfated polysaccharide of a MW of 2,000 (Polyanion SP 54) also enhanced the anti Xa-activity. This effect was dose dependent and was comparable to the action of heparin when the substances were tested in a purified system. In plasmatic environment,the anti Xa-activity was lower than the anti Xa-effect of heparin when bovine factor Xa was added to the test system but was less evident when activation of factor Xa was carried out in the test plasma. The antithrombin effect of SP 54 was negligible and was about 4 per cent of the antithrombin effect of heparin. After subcutaneous injection of SP 54,its anti Xa-effect was superior to the effect of a comparable dose of heparin. As a consequence of the low antithrombin potentiating effect,the results of coagulation tests with exception of the aPTT were not influenced by SP 54." @default.
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- W2034454838 date "1980-10-01" @default.
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- W2034454838 title "Influence on the clotting mechanism of sodium pentosan polysulfate (SP54) in comparison to commercial beef lung sodium heparin" @default.
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- W2034454838 doi "https://doi.org/10.1016/0049-3848(80)90056-0" @default.
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