Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034454841> ?p ?o ?g. }
- W2034454841 endingPage "11" @default.
- W2034454841 startingPage "2" @default.
- W2034454841 abstract "Background: schizophrenia's endophenotipic profile is not only generally complex, but often varies from case to case. The perspective of trying to define specific anatomic correlates of the syndrome has led to disappointing results. In that context, neurophysiologic hypotheses (e.g. glutamatergic hypothesis) and connectivity hypotheses became prominent. Nevertheless, despite their commitment to the principle of denying ‘localist’ views and approaching the syndrome's endophenotype from a whole brain perspective, efforts to integrate both have not flourished at this moment in time. Objectives: This paper aims to introduce a new etiological model that integrates the glutamatergic and the WM (WM) hypotheses of schizophrenia's etiology. This model proposes to serve as a framework in order to relate to patterns of brain abnormalities from the onset of the syndrome to stages of advanced chronification. Highlights: Neurotransmitter abnormalities forego noticeable WM abnormalities. The former, chiefly represented by NMDAR hypo-function and associated molecular cascades, is related to the first signs of cell loss. This process is both directly and indirectly integrated to the underpinning of WM structural abnormalities; not only is the excess of glutamate toxic to the WM, but its disruption is associated to the expression of known genetic risk factors (e.g., NRG-1). A second level of the model develops the idea that abnormal neurotransmission within specific neural populations (‘motifs’) impair particular cognitive abilities, while subsequent WM structural abnormalities impair the integration of brain functions and multimodality. As a result of this two-stage dynamic, the affected individual progresses from experiencing specific cognitive and psychological deficits, to a condition of cognitive and existential fragmentation, linked to hardly reversible decreases in psychosocial functioning. Keywords: Schizophrenia, molecular psychiatry, connectivity, glutamate, white matter, hypofrontal activation, DSM, psychiatric cohorts, vasopressin, angiotensin, pharmacology" @default.
- W2034454841 created "2016-06-24" @default.
- W2034454841 creator A5062633326 @default.
- W2034454841 date "2012-03-01" @default.
- W2034454841 modified "2023-09-27" @default.
- W2034454841 title "The Integration of the Glutamatergic and the White Matter Hypotheses of Schizophrenias Etiology" @default.
- W2034454841 cites W1503837951 @default.
- W2034454841 cites W1509285273 @default.
- W2034454841 cites W1514196021 @default.
- W2034454841 cites W1592395635 @default.
- W2034454841 cites W1967786852 @default.
- W2034454841 cites W1968584106 @default.
- W2034454841 cites W1970814820 @default.
- W2034454841 cites W1973316101 @default.
- W2034454841 cites W1973502710 @default.
- W2034454841 cites W1974532559 @default.
- W2034454841 cites W1977768384 @default.
- W2034454841 cites W1980122382 @default.
- W2034454841 cites W1981473462 @default.
- W2034454841 cites W1985316884 @default.
- W2034454841 cites W1986068219 @default.
- W2034454841 cites W1987815409 @default.
- W2034454841 cites W1994564621 @default.
- W2034454841 cites W1995586257 @default.
- W2034454841 cites W1995731471 @default.
- W2034454841 cites W1996379253 @default.
- W2034454841 cites W1997111256 @default.
- W2034454841 cites W1998812993 @default.
- W2034454841 cites W2001055163 @default.
- W2034454841 cites W2004559917 @default.
- W2034454841 cites W2005197141 @default.
- W2034454841 cites W2005726303 @default.
- W2034454841 cites W2009307684 @default.
- W2034454841 cites W2009650955 @default.
- W2034454841 cites W2015867840 @default.
- W2034454841 cites W2017806432 @default.
- W2034454841 cites W2020173072 @default.
- W2034454841 cites W2020237866 @default.
- W2034454841 cites W2021489201 @default.
- W2034454841 cites W2022809683 @default.
- W2034454841 cites W2025008591 @default.
- W2034454841 cites W2026892549 @default.
- W2034454841 cites W2028554055 @default.
- W2034454841 cites W2030553916 @default.
- W2034454841 cites W2031443679 @default.
- W2034454841 cites W2032147029 @default.
- W2034454841 cites W2033078279 @default.
- W2034454841 cites W2033368297 @default.
- W2034454841 cites W2037623380 @default.
- W2034454841 cites W2038381254 @default.
- W2034454841 cites W2040260476 @default.
- W2034454841 cites W2040854639 @default.
- W2034454841 cites W2044004318 @default.
- W2034454841 cites W2044309727 @default.
- W2034454841 cites W2049212652 @default.
- W2034454841 cites W2049973822 @default.
- W2034454841 cites W2050984501 @default.
- W2034454841 cites W2051698659 @default.
- W2034454841 cites W2052025169 @default.
- W2034454841 cites W2054484015 @default.
- W2034454841 cites W2058711140 @default.
- W2034454841 cites W2061579840 @default.
- W2034454841 cites W2063505213 @default.
- W2034454841 cites W2065003979 @default.
- W2034454841 cites W2066003443 @default.
- W2034454841 cites W2066635264 @default.
- W2034454841 cites W2068702172 @default.
- W2034454841 cites W2070297302 @default.
- W2034454841 cites W2073192094 @default.
- W2034454841 cites W2074601803 @default.
- W2034454841 cites W2079937681 @default.
- W2034454841 cites W2079999567 @default.
- W2034454841 cites W2080234318 @default.
- W2034454841 cites W2082929629 @default.
- W2034454841 cites W2084107770 @default.
- W2034454841 cites W2084120702 @default.
- W2034454841 cites W2084200464 @default.
- W2034454841 cites W2086358843 @default.
- W2034454841 cites W2087708838 @default.
- W2034454841 cites W2087779979 @default.
- W2034454841 cites W2087866447 @default.
- W2034454841 cites W2089674775 @default.
- W2034454841 cites W2089762801 @default.
- W2034454841 cites W2090409162 @default.
- W2034454841 cites W2093625493 @default.
- W2034454841 cites W2095849695 @default.
- W2034454841 cites W2095865456 @default.
- W2034454841 cites W2096448210 @default.
- W2034454841 cites W2108050527 @default.
- W2034454841 cites W2108422856 @default.
- W2034454841 cites W2110496616 @default.
- W2034454841 cites W2110835949 @default.
- W2034454841 cites W2112090702 @default.
- W2034454841 cites W2113312906 @default.
- W2034454841 cites W2114091391 @default.
- W2034454841 cites W2118775806 @default.
- W2034454841 cites W2119022356 @default.
- W2034454841 cites W2119619841 @default.