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• W2034455209 startingPage "253" @default.
• W2034455209 abstract "Although the endothelial cell is considered antithrombogenic, endothelium has recently been shown to participate in procoagulant reactions. Factor IX bound to specific endothelial cell sites can be activated by the intrinsic and extrinsic pathways of coagulation. Perturbation of endothelium results in induction of tissue factor which promotes factor VIIa-mediated activation of factors IX and X. thus initiating procoagulant events on the endothelial surface. Cell bound factor IXa, in the presence of factor VIII, promotes activation of factor X. The factor Xa formed can interact with endothelial cell factor V/Va, resulting in prothrombin activation. Thrombin then cleaves fibrinogen and a fibrin clot closely associated with the endothelial cell forms. The perturbed endothelial cell thus provides a focus of localized procoagulant events. This model suggests a simple endothelial-cell-dependent mechanism for initiation of coagulation at the site of an injured or pathological vessel." @default.
• W2034455209 created "2016-06-24" @default.
• W2034455209 creator A5067599146 @default.
• W2034455209 creator A5071638419 @default.
• W2034455209 date "1985-01-01" @default.
• W2034455209 modified "2023-09-25" @default.
• W2034455209 title "A pathway of coagulation on endothelial cells" @default.
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• W2034455209 doi "https://doi.org/10.1002/jcb.240280403" @default.
• W2034455209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3877062" @default.
• W2034455209 hasPublicationYear "1985" @default.
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