Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034457197> ?p ?o ?g. }
- W2034457197 endingPage "380" @default.
- W2034457197 startingPage "365" @default.
- W2034457197 abstract "The post-translational modification of serine and threonine residues of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is highly ubiquitous, dynamic and inducible. Protein O-GlcNAcylation serves as a key regulator of critical biological processes including transcription, translation, proteasomal degradation, signal transduction and apoptosis. Increased O-GlcNAcylation is directly linked to insulin resistance and to hyperglycemia-induced glucose toxicity, two hallmarks of diabetes and diabetic complications. In this review, we briefly summarize what is known about protein O-GlcNAcylation and nutrient metabolism, as well as discuss the commonly used tools to probe changes of O-GlcNAcylation in cultured cells and in animal models. We then focus on some key proteins modified by O-GlcNAc, which play crucial roles in the etiology and progression of diabetes and diabetic complications. Proteomic approaches are also highlighted to provide a system view of protein O-GlcNAcylation. Finally, we discuss how aberrant O-GlcNAcylation on certain proteins may be exploited to develop methods for the early diagnosis of pre-diabetes and/or diabetes." @default.
- W2034457197 created "2016-06-24" @default.
- W2034457197 creator A5042680625 @default.
- W2034457197 creator A5043863262 @default.
- W2034457197 date "2013-08-01" @default.
- W2034457197 modified "2023-10-17" @default.
- W2034457197 title "Protein<i>O</i>-GlcNAcylation in diabetes and diabetic complications" @default.
- W2034457197 cites W1481480776 @default.
- W2034457197 cites W1516265214 @default.
- W2034457197 cites W1540964771 @default.
- W2034457197 cites W1590732591 @default.
- W2034457197 cites W1601059079 @default.
- W2034457197 cites W1605680188 @default.
- W2034457197 cites W1652316604 @default.
- W2034457197 cites W1711248712 @default.
- W2034457197 cites W1968005873 @default.
- W2034457197 cites W1968813770 @default.
- W2034457197 cites W1969939865 @default.
- W2034457197 cites W1970261233 @default.
- W2034457197 cites W1971412377 @default.
- W2034457197 cites W1974691400 @default.
- W2034457197 cites W1979095700 @default.
- W2034457197 cites W1980196380 @default.
- W2034457197 cites W1981194148 @default.
- W2034457197 cites W1982371325 @default.
- W2034457197 cites W1982409123 @default.
- W2034457197 cites W1982416292 @default.
- W2034457197 cites W1985251960 @default.
- W2034457197 cites W1987990773 @default.
- W2034457197 cites W1989928461 @default.
- W2034457197 cites W1991587502 @default.
- W2034457197 cites W1992897888 @default.
- W2034457197 cites W1993790829 @default.
- W2034457197 cites W1997087248 @default.
- W2034457197 cites W1997304347 @default.
- W2034457197 cites W1997853510 @default.
- W2034457197 cites W1998630548 @default.
- W2034457197 cites W1998906741 @default.
- W2034457197 cites W2000325349 @default.
- W2034457197 cites W2000652481 @default.
- W2034457197 cites W2003376195 @default.
- W2034457197 cites W2005886610 @default.
- W2034457197 cites W2006296741 @default.
- W2034457197 cites W2009779581 @default.
- W2034457197 cites W2017614262 @default.
- W2034457197 cites W2022428368 @default.
- W2034457197 cites W2022647011 @default.
- W2034457197 cites W2025748859 @default.
- W2034457197 cites W2027655677 @default.
- W2034457197 cites W2030205108 @default.
- W2034457197 cites W2031087463 @default.
- W2034457197 cites W2031957765 @default.
- W2034457197 cites W2033125833 @default.
- W2034457197 cites W2033832954 @default.
- W2034457197 cites W2035680903 @default.
- W2034457197 cites W2035837644 @default.
- W2034457197 cites W2037333220 @default.
- W2034457197 cites W2037559709 @default.
- W2034457197 cites W2038188127 @default.
- W2034457197 cites W2041744455 @default.
- W2034457197 cites W2041892500 @default.
- W2034457197 cites W2044437167 @default.
- W2034457197 cites W2044688375 @default.
- W2034457197 cites W2048870206 @default.
- W2034457197 cites W2050560857 @default.
- W2034457197 cites W2050775180 @default.
- W2034457197 cites W2051948190 @default.
- W2034457197 cites W2052135200 @default.
- W2034457197 cites W2053017792 @default.
- W2034457197 cites W2053531649 @default.
- W2034457197 cites W2054154819 @default.
- W2034457197 cites W2054664745 @default.
- W2034457197 cites W2054722953 @default.
- W2034457197 cites W2056173710 @default.
- W2034457197 cites W2058370904 @default.
- W2034457197 cites W2059556669 @default.
- W2034457197 cites W2060744329 @default.
- W2034457197 cites W2062236151 @default.
- W2034457197 cites W2063245300 @default.
- W2034457197 cites W2065955997 @default.
- W2034457197 cites W2066290187 @default.
- W2034457197 cites W2067729127 @default.
- W2034457197 cites W2068322375 @default.
- W2034457197 cites W2068805128 @default.
- W2034457197 cites W2069052453 @default.
- W2034457197 cites W2070859810 @default.
- W2034457197 cites W2071520055 @default.
- W2034457197 cites W2072135796 @default.
- W2034457197 cites W2074146315 @default.
- W2034457197 cites W2074332237 @default.
- W2034457197 cites W2075375055 @default.
- W2034457197 cites W2076651708 @default.
- W2034457197 cites W2078911958 @default.
- W2034457197 cites W2079977692 @default.
- W2034457197 cites W2084492188 @default.
- W2034457197 cites W2087910122 @default.
- W2034457197 cites W2089465141 @default.
- W2034457197 cites W2089693526 @default.