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• W2034457951 abstract "Transferrin (Tf) was immobilized onto Fe3O4@SiO2 nanoparticles with high doxorubicin (DOX) loading (TfDMP), for dual targeting of cancer, by chemically coupling both Tf and DOX with dual-function magnetic nanoparticles (DMPs) using a multi-armed crosslinker, poly-L-glutamic acid. With high trapping efficiency for magnetic targeting, TfDMP exhibits a Tf receptor-targeting function. Moreover, the DOX loading percentage of TfDMP is high, and can be controlled by adjusting the reactant ratio. TfDMP presents a narrow size distribution, and is sensitive to pH for drug release. Compared with DOX-coupled DMP without Tf modification (DDMP), TfDMP exhibits enhanced uptake by Tf receptor-expressing tumor cells, and displays stronger cancer cell cytotoxicity. This study provides an efficient method for the dual-targeted delivery of therapeutic agents to tumors, with controlled low carrier toxicity and high efficiency." @default.
• W2034457951 created "2016-06-24" @default.
• W2034457951 creator A5041341697 @default.
• W2034457951 creator A5046361413 @default.
• W2034457951 date "2013-12-01" @default.
• W2034457951 modified "2023-10-02" @default.
• W2034457951 title "Immobilized transferrin Fe3O4@SiO2 nanoparticle with high doxorubicin loading for dual-targeted tumor drug delivery" @default.
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• W2034457951 doi "https://doi.org/10.2147/ijn.s51745" @default.
• W2034457951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3857267" @default.
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• W2034457951 hasPublicationYear "2013" @default.
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