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• W2034458178 abstract "Background The initial surgical management of asymptomatic patients with unresectable stage IV colorectal cancer (CRC) is still controversy. The aim of this study was to compare the incidence of major intestinal complications in asymptomatic patients who received palliative treatment for unresectable stage IV CRC, according to the type of treatment. Methods Between March 2001 and January 2008, we retrospectively analyzed 227 asymptomatic patients who underwent first-line resection of the primary tumor followed by chemotherapy (144 patients, resection group) or those who underwent first-line chemotherapy (83 patients, chemotherapy group). Results In the resection group, the incidences of intestinal obstruction, peritonitis, fistula, and intestinal hemorrhage were 14.6%, 0%, 0.7%, and 4.8%, respectively. In the chemotherapy group, these incidences were 15.2%, 1.2%, 0%, and 3.5%, respectively. There were no significant differences between the two groups in terms of intestinal complications. In multivariate analysis of overall survival, treatment type (resection group vs. chemotherapy group) was not a significant prognostic factor (P = 0.076). Conclusions In asymptomatic patients with unresectable stage IV CRC, first-line chemotherapy may be considered safe, with no increased risk of major intestinal complications compared with primary tumor resection plus chemotherapy. J. Surg. Oncol. J. Surg. Oncol. 2010;102:94–99. © 2010 Wiley-Liss, Inc." @default.
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• W2034458178 date "2010-04-28" @default.
• W2034458178 modified "2023-10-12" @default.
• W2034458178 title "Intestinal complications after palliative treatment for asymptomatic patients with unresectable stage IV colorectal cancer" @default.
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• W2034458178 doi "https://doi.org/10.1002/jso.21577" @default.
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