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• W2034458356 abstract "Purpose The purpose of this study was to investigate the effect of changes in partial pressure of arterial CO2 (PaCO2) on oral tissue blood flow. Materials and Methods Twenty male tracheotomized Japan white rabbits were anesthetized with isoflurane (ISO) or propofol (PROP) under mechanical ventilation. Observed variables included heart rate, blood pressure, common carotid artery blood flow (CBF), and tissue blood flow of the mandibular bone marrow (BBF), the masseter muscle (MBF), and the mandibular periosteum (PBF). After completion of experimental preparation, CO2 was added to inspired gas to change the inspired CO2 tension. Measurements were performed with end-tidal CO2 tension (ETCO2) maintained at 30, 40, 50, and 60 mmHg. Results Heart rate in both groups gradually decreased with increasing ETCO2. In contrast, both systolic and diastolic arterial pressures gradually increased with increasing ETCO2. Both CBF and BBF increased and MBF decreased with increasing ETCO2. PBF showed no change throughout the experiment. A positive relationship was observed between CBF and BBF; in contrast, a negative relationship was observed between CBF and MBF. Conclusion Changes in PaCO2 may induce a redistribution of oral tissue blood flow during both ISO and PROP anesthesia. The purpose of this study was to investigate the effect of changes in partial pressure of arterial CO2 (PaCO2) on oral tissue blood flow. Twenty male tracheotomized Japan white rabbits were anesthetized with isoflurane (ISO) or propofol (PROP) under mechanical ventilation. Observed variables included heart rate, blood pressure, common carotid artery blood flow (CBF), and tissue blood flow of the mandibular bone marrow (BBF), the masseter muscle (MBF), and the mandibular periosteum (PBF). After completion of experimental preparation, CO2 was added to inspired gas to change the inspired CO2 tension. Measurements were performed with end-tidal CO2 tension (ETCO2) maintained at 30, 40, 50, and 60 mmHg. Heart rate in both groups gradually decreased with increasing ETCO2. In contrast, both systolic and diastolic arterial pressures gradually increased with increasing ETCO2. Both CBF and BBF increased and MBF decreased with increasing ETCO2. PBF showed no change throughout the experiment. A positive relationship was observed between CBF and BBF; in contrast, a negative relationship was observed between CBF and MBF. Changes in PaCO2 may induce a redistribution of oral tissue blood flow during both ISO and PROP anesthesia." @default.
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• W2034458356 date "2008-09-01" @default.
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• W2034458356 title "Changes in Partial Pressure of Arterial Carbon Dioxide Induces Redistribution of Oral Tissue Blood Flow in the Rabbit" @default.
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• W2034458356 doi "https://doi.org/10.1016/j.joms.2007.09.010" @default.
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