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- W2034458720 abstract "In Drosophila embryos, muscle fiber formation via myoblast fusion relies on essential contributions made by the conserved Arp2/3 microfilament nucleation machinery. Two key nucleation promoting factors (NPFs), SCAR and WASp, have been shown to mediate this aspect of Arp2/3 function. We have used these unique circumstances, to study the requirements and coordination of distinct NPF activities, within a common developmental setting. Our results suggest that, although operating within close spatial and temporal proximity, the two regulators of actin polymerization are used in a step-wise manner and perform separate functional roles. Our approach also allows us to assess the involvement of the Arp2/3 machinery in formation of a distinct, fusion-associated actin structure." @default.
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- W2034458720 date "2010-04-15" @default.
- W2034458720 modified "2023-09-23" @default.
- W2034458720 title "Making muscles- Arp, two, three" @default.
- W2034458720 doi "https://doi.org/10.4161/fly.4.2.10954" @default.
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