FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034459058> ?p ?o ?g. }

• W2034459058 abstract "Experimental investigation of cerebral mechanisms underlying pain and analgesia are important in the development of methods for diagnosis and treatment of pain. The aim of the current study was to explore brain metabolites in response to pain and treatment with morphine.Proton magnetic resonance spectroscopy of the anterior cingulate cortex was performed in 20 healthy volunteers (13 males and seven females, aged 24.9±2.6 years) during rest and acute pain before and during treatment with 30 mg of oral morphine or placebo in a randomized, double-blinded, cross-over study design. Pain was evoked by skin stimulation applied to the right upper leg using a contact heat-evoked potential stimulator.Data from 12 subjects were valid for analysis. Painful stimulation induced an increase in N-acetylaspartate/creatine compared with rest (F=5.5, P=0.04). During treatment with morphine, painful stimulation induced decreased glutamate/creatine (F=7.3, P=0.02), myo-inositol/creatine (F=8.38, P=0.02), and N-acetylaspartate/creatine (F=13.8, P=0.004) concentrations, whereas an increase in the pain-evoked N-acetylaspartate/creatine concentration (F=6.1, P=0.04) was seen during treatment with placebo.This explorative study indicates that neuronal metabolites in the anterior cingulate cortex, such as N-acetylaspartate, glutamate, and myo-inositol, could be related to the physiology of pain and treatment with morphine. This experimental method has the potential to enable the study of brain metabolites involved in pain and its treatment, and may in the future be used to provide further insight into these mechanisms." @default.
• W2034459058 created "2016-06-24" @default.
• W2034459058 creator A5005849832 @default.
• W2034459058 creator A5052030211 @default.
• W2034459058 creator A5058714238 @default.
• W2034459058 creator A5073299507 @default.
• W2034459058 creator A5086237037 @default.
• W2034459058 date "2014-05-01" @default.
• W2034459058 modified "2023-09-27" @default.
• W2034459058 title "Cingulate metabolites during pain and morphine treatment as assessed by magnetic resonance spectroscopy" @default.
• W2034459058 cites W1521817642 @default.
• W2034459058 cites W1730237872 @default.
• W2034459058 cites W1894299641 @default.
• W2034459058 cites W1964014908 @default.
• W2034459058 cites W1972883925 @default.
• W2034459058 cites W1978571756 @default.
• W2034459058 cites W1980929508 @default.
• W2034459058 cites W1993826155 @default.
• W2034459058 cites W1996779174 @default.
• W2034459058 cites W1999108896 @default.
• W2034459058 cites W2030788682 @default.
• W2034459058 cites W2033841207 @default.
• W2034459058 cites W2038979894 @default.
• W2034459058 cites W2044808665 @default.
• W2034459058 cites W2049362778 @default.
• W2034459058 cites W2050643537 @default.
• W2034459058 cites W2054891027 @default.
• W2034459058 cites W2068437254 @default.
• W2034459058 cites W2075058317 @default.
• W2034459058 cites W2077729190 @default.
• W2034459058 cites W2086504454 @default.
• W2034459058 cites W2094347820 @default.
• W2034459058 cites W2096172823 @default.
• W2034459058 cites W2100251061 @default.
• W2034459058 cites W2101829719 @default.
• W2034459058 cites W2102118295 @default.
• W2034459058 cites W2122393149 @default.
• W2034459058 cites W2128181061 @default.
• W2034459058 cites W2131165483 @default.
• W2034459058 cites W2134539998 @default.
• W2034459058 cites W2144867092 @default.
• W2034459058 cites W345364767 @default.
• W2034459058 doi "https://doi.org/10.2147/jpr.s61193" @default.
• W2034459058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4038455" @default.
• W2034459058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24899823" @default.
• W2034459058 hasPublicationYear "2014" @default.
• W2034459058 type Work @default.
• W2034459058 sameAs 2034459058 @default.
• W2034459058 citedByCount "10" @default.
• W2034459058 countsByYear W20344590582017 @default.
• W2034459058 countsByYear W20344590582018 @default.
• W2034459058 countsByYear W20344590582019 @default.
• W2034459058 countsByYear W20344590582020 @default.
• W2034459058 countsByYear W20344590582021 @default.
• W2034459058 countsByYear W20344590582023 @default.
• W2034459058 crossrefType "journal-article" @default.
• W2034459058 hasAuthorship W2034459058A5005849832 @default.
• W2034459058 hasAuthorship W2034459058A5052030211 @default.
• W2034459058 hasAuthorship W2034459058A5058714238 @default.
• W2034459058 hasAuthorship W2034459058A5073299507 @default.
• W2034459058 hasAuthorship W2034459058A5086237037 @default.
• W2034459058 hasBestOaLocation W20344590581 @default.
• W2034459058 hasConcept C118552586 @default.
• W2034459058 hasConcept C126322002 @default.
• W2034459058 hasConcept C126838900 @default.
• W2034459058 hasConcept C142724271 @default.
• W2034459058 hasConcept C143409427 @default.
• W2034459058 hasConcept C169900460 @default.
• W2034459058 hasConcept C170493617 @default.
• W2034459058 hasConcept C204787440 @default.
• W2034459058 hasConcept C24998067 @default.
• W2034459058 hasConcept C27081682 @default.
• W2034459058 hasConcept C2777389121 @default.
• W2034459058 hasConcept C2778402161 @default.
• W2034459058 hasConcept C2779896295 @default.
• W2034459058 hasConcept C2781210436 @default.
• W2034459058 hasConcept C42219234 @default.
• W2034459058 hasConcept C529278444 @default.
• W2034459058 hasConcept C61174792 @default.
• W2034459058 hasConcept C71924100 @default.
• W2034459058 hasConceptScore W2034459058C118552586 @default.
• W2034459058 hasConceptScore W2034459058C126322002 @default.
• W2034459058 hasConceptScore W2034459058C126838900 @default.
• W2034459058 hasConceptScore W2034459058C142724271 @default.
• W2034459058 hasConceptScore W2034459058C143409427 @default.
• W2034459058 hasConceptScore W2034459058C169900460 @default.
• W2034459058 hasConceptScore W2034459058C170493617 @default.
• W2034459058 hasConceptScore W2034459058C204787440 @default.
• W2034459058 hasConceptScore W2034459058C24998067 @default.
• W2034459058 hasConceptScore W2034459058C27081682 @default.
• W2034459058 hasConceptScore W2034459058C2777389121 @default.
• W2034459058 hasConceptScore W2034459058C2778402161 @default.
• W2034459058 hasConceptScore W2034459058C2779896295 @default.
• W2034459058 hasConceptScore W2034459058C2781210436 @default.
• W2034459058 hasConceptScore W2034459058C42219234 @default.
• W2034459058 hasConceptScore W2034459058C529278444 @default.
• W2034459058 hasConceptScore W2034459058C61174792 @default.
• W2034459058 hasConceptScore W2034459058C71924100 @default.
• W2034459058 hasLocation W20344590581 @default.
• W2034459058 hasLocation W20344590582 @default.

• next