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- W2034459090 abstract "The therapeutic potential of transplantation of insulin-secreting pancreatic beta-cells has stimulated interest in using pluripotent embryonic stem (ES) cells as a starting material from which to generate insulin secreting cells in vitro. Mature beta-cells are endodermal in origin so most reported differentiation protocols rely on the identification of endoderm-specific markers. However, endoderm development is an early event in embryogenesis that produces cells destined for the gut and associated organs in the embryo, and for the development of extra-embryonic structures such as the yolk sac. We have demonstrated that mouse ES cells readily differentiate into extra-embryonic endoderm in vitro, and that these cell populations express the insulin gene and other functional elements associated with beta-cells. We suggest that the insulin-expressing cells generated in this and other studies are not authentic pancreatic beta-cells, but may be of extra-embryonic endodermal origin." @default.
- W2034459090 created "2016-06-24" @default.
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- W2034459090 date "2005-03-01" @default.
- W2034459090 modified "2023-09-23" @default.
- W2034459090 title "Generation of insulin-expressing cells from mouse embryonic stem cells" @default.
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- W2034459090 doi "https://doi.org/10.1016/j.bbrc.2004.12.183" @default.
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