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• W2034459296 abstract "Poly(N-isopropylacrylamide) (PNIPAAm)/calcium phosphate (CaP) hybrid nanocomposites with dual-responsive controlled drug delivery property have been prepared by in-situ biomineralization process. Poly(acrylic acid) (PAA) is used as a crystal growth additive to control the morphology of the hybrid nanocomposites. The interaction between PAA and Ca2+ contributes to the formation of homogeneous and robust nanocomposites. Vitamin B2 release behavior is found to be pH- and thermal-responsive. Additionally, the release profiles are sustained with the introduction of CaP, indicating that CaP nanocrystallines could decrease the permeation of the encapsulated drug effectively. The results suggest that the prepared hybrid nanocomposites can be used as “smart” nanoscale materials for sustained dual-responsive drug delivery." @default.
• W2034459296 created "2016-06-24" @default.
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• W2034459296 date "2012-07-01" @default.
• W2034459296 modified "2023-10-16" @default.
• W2034459296 title "Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery" @default.
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• W2034459296 doi "https://doi.org/10.1016/j.msec.2012.04.008" @default.
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