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• W2034463892 abstract "•We predicted risk factors for methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia and mortality in cases with S. aureus bacteraemia.•A high HIV prevalence (32%) occurred in S. aureus bacteraemia cases.•MRSA infections were non-susceptible to multiple antibiotics.•HIV infection, among others, was a risk factor for MRSA bacteraemia.•The 25–44 years age group was significantly associated with mortality among cases with S. aureus bacteraemia. IntroductionMethicillin-resistant Staphylococcus aureus (MRSA) infections are responsible for longer hospital stays, increased hospital costs, and poorer outcomes compared to methicillin-sensitive S. aureus (MSSA) infections. We aimed to describe the epidemiology of S. aureus bacteraemia (SAB) and to determine factors associated with MRSA infection in South Africa.MethodsCases of SAB were reported from September 2012 to September 2013 from three sentinel sites. A case was defined as the isolation of S. aureus from a blood culture during a 21-day period. Detailed clinical information was collected. Multivariable logistic regression was done to determine factors associated with MRSA infection and mortality.ResultsThere were 442 cases of SAB reported; antimicrobial susceptibility testing was performed on 240 isolates (54%). Thirty-six percent (86/240) of cases had an MRSA infection. A longer hospital stay before positive specimen collection (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.02–1.13, p = 0.004), hospitalization in the last year (OR 15.7, 95% CI 2.5–99.5, p = 0.003), HIV infection (OR 4.9, 95% CI 1.05–22.90, p = 0.044), and antibiotic use in the previous 2 months (OR 0.1, 95% CI 0.01–0.68, p = 0.022) were independent predictors of MRSA. Older age, and in particular age 25–44 years (OR 22.2, 95% CI 2.7–185.5, p = 0.004, compared to those aged < 5 years), was the only independent predictor of mortality amongst cases with SAB. MRSA isolates were non-susceptible to more antimicrobial agents compared to MSSA isolates.ConclusionsHIV infection was an independent risk factor for MRSA infection. The selection of appropriate empirical antimicrobial treatment is essential in patients with MRSA infections because of non-susceptibility to many other antimicrobial classes. Methicillin-resistant Staphylococcus aureus (MRSA) infections are responsible for longer hospital stays, increased hospital costs, and poorer outcomes compared to methicillin-sensitive S. aureus (MSSA) infections. We aimed to describe the epidemiology of S. aureus bacteraemia (SAB) and to determine factors associated with MRSA infection in South Africa. Cases of SAB were reported from September 2012 to September 2013 from three sentinel sites. A case was defined as the isolation of S. aureus from a blood culture during a 21-day period. Detailed clinical information was collected. Multivariable logistic regression was done to determine factors associated with MRSA infection and mortality. There were 442 cases of SAB reported; antimicrobial susceptibility testing was performed on 240 isolates (54%). Thirty-six percent (86/240) of cases had an MRSA infection. A longer hospital stay before positive specimen collection (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.02–1.13, p = 0.004), hospitalization in the last year (OR 15.7, 95% CI 2.5–99.5, p = 0.003), HIV infection (OR 4.9, 95% CI 1.05–22.90, p = 0.044), and antibiotic use in the previous 2 months (OR 0.1, 95% CI 0.01–0.68, p = 0.022) were independent predictors of MRSA. Older age, and in particular age 25–44 years (OR 22.2, 95% CI 2.7–185.5, p = 0.004, compared to those aged < 5 years), was the only independent predictor of mortality amongst cases with SAB. MRSA isolates were non-susceptible to more antimicrobial agents compared to MSSA isolates. HIV infection was an independent risk factor for MRSA infection. The selection of appropriate empirical antimicrobial treatment is essential in patients with MRSA infections because of non-susceptibility to many other antimicrobial classes." @default.
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• W2034463892 date "2015-01-01" @default.
• W2034463892 modified "2023-10-01" @default.
• W2034463892 title "Staphylococcus aureus bacteraemia in Gauteng academic hospitals, South Africa" @default.
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• W2034463892 doi "https://doi.org/10.1016/j.ijid.2014.10.011" @default.
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