Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034472018> ?p ?o ?g. }
- W2034472018 endingPage "1292" @default.
- W2034472018 startingPage "1281" @default.
- W2034472018 abstract "To compare levels of HLA-DR expression in rheumatoid arthritis (RA) patients and healthy controls for whom an ordered expression according to the DR alleles is demonstrated and to test the functional consequences of this expression on peptide presentation.Using monoclonal antibodies that recognize different DRB1 alleles, DR molecules were quantitated at the surface of the peripheral blood B cells of 23 RA patients and 17 healthy subjects. The functional consequences of the level of DR surface expression was tested using a universal model of antigen presentation and mutated peptides with variable affinities for the T cell receptor.In healthy subjects, surface HLA-DR molecules were expressed at different levels according to allele (DR53, DR4, and DR11 less than DR1 less than DR7 less than DR15). In RA patients, this hierarchy was not conserved and, furthermore, the density of RA-associated DR4 and DR1 molecules was enhanced in patients compared with the basal density in healthy individuals. We demonstrated that an increased expression of DR molecules at the surface of antigen-presenting cells allowed a noteworthy presentation of low-affinity peptides that under normal conditions are not efficient in generating a T cell response at physiologic surface density of the DR molecules.Our results suggest that the specific overexpression of RA-associated HLA molecules could be responsible for the presentation of low-affinity autopeptides and therefore the activation of peripheral autoreactive T cells." @default.
- W2034472018 created "2016-06-24" @default.
- W2034472018 creator A5008811878 @default.
- W2034472018 creator A5009456121 @default.
- W2034472018 creator A5044915223 @default.
- W2034472018 creator A5050585732 @default.
- W2034472018 creator A5071473214 @default.
- W2034472018 creator A5074261246 @default.
- W2034472018 creator A5075112000 @default.
- W2034472018 date "2001-01-01" @default.
- W2034472018 modified "2023-10-16" @default.
- W2034472018 title "Specific overexpression of rheumatoid arthritis-associated HLA-DR alleles and presentation of low-affinity peptides" @default.
- W2034472018 cites W1543295101 @default.
- W2034472018 cites W1546199871 @default.
- W2034472018 cites W1553552126 @default.
- W2034472018 cites W1564040129 @default.
- W2034472018 cites W1566811483 @default.
- W2034472018 cites W1580105830 @default.
- W2034472018 cites W1588864421 @default.
- W2034472018 cites W1593721388 @default.
- W2034472018 cites W1595789911 @default.
- W2034472018 cites W1770261978 @default.
- W2034472018 cites W1884828489 @default.
- W2034472018 cites W1895674153 @default.
- W2034472018 cites W1967985283 @default.
- W2034472018 cites W1976890962 @default.
- W2034472018 cites W1999436383 @default.
- W2034472018 cites W2000533294 @default.
- W2034472018 cites W2000784101 @default.
- W2034472018 cites W2005817811 @default.
- W2034472018 cites W2007731109 @default.
- W2034472018 cites W2015865604 @default.
- W2034472018 cites W2018728644 @default.
- W2034472018 cites W2021986528 @default.
- W2034472018 cites W2022233302 @default.
- W2034472018 cites W2028321111 @default.
- W2034472018 cites W2032169064 @default.
- W2034472018 cites W2036073746 @default.
- W2034472018 cites W2037122537 @default.
- W2034472018 cites W2040343562 @default.
- W2034472018 cites W2041089253 @default.
- W2034472018 cites W2043701906 @default.
- W2034472018 cites W2056178732 @default.
- W2034472018 cites W2062619192 @default.
- W2034472018 cites W2071492067 @default.
- W2034472018 cites W2072595857 @default.
- W2034472018 cites W2076923050 @default.
- W2034472018 cites W2077017900 @default.
- W2034472018 cites W2084649199 @default.
- W2034472018 cites W2091627789 @default.
- W2034472018 cites W2092643850 @default.
- W2034472018 cites W2114198373 @default.
- W2034472018 cites W2121024497 @default.
- W2034472018 cites W2121203525 @default.
- W2034472018 cites W2124179809 @default.
- W2034472018 cites W2144818921 @default.
- W2034472018 cites W2152348310 @default.
- W2034472018 cites W2158345511 @default.
- W2034472018 cites W2160788240 @default.
- W2034472018 cites W2162283184 @default.
- W2034472018 cites W2163295981 @default.
- W2034472018 cites W2163306718 @default.
- W2034472018 cites W4365441822 @default.
- W2034472018 doi "https://doi.org/10.1002/1529-0131(200106)44:6<1281::aid-art220>3.0.co;2-2" @default.
- W2034472018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11407687" @default.
- W2034472018 hasPublicationYear "2001" @default.
- W2034472018 type Work @default.
- W2034472018 sameAs 2034472018 @default.
- W2034472018 citedByCount "17" @default.
- W2034472018 countsByYear W20344720182012 @default.
- W2034472018 countsByYear W20344720182013 @default.
- W2034472018 countsByYear W20344720182014 @default.
- W2034472018 countsByYear W20344720182015 @default.
- W2034472018 countsByYear W20344720182016 @default.
- W2034472018 crossrefType "journal-article" @default.
- W2034472018 hasAuthorship W2034472018A5008811878 @default.
- W2034472018 hasAuthorship W2034472018A5009456121 @default.
- W2034472018 hasAuthorship W2034472018A5044915223 @default.
- W2034472018 hasAuthorship W2034472018A5050585732 @default.
- W2034472018 hasAuthorship W2034472018A5071473214 @default.
- W2034472018 hasAuthorship W2034472018A5074261246 @default.
- W2034472018 hasAuthorship W2034472018A5075112000 @default.
- W2034472018 hasConcept C104317684 @default.
- W2034472018 hasConcept C126322002 @default.
- W2034472018 hasConcept C147483822 @default.
- W2034472018 hasConcept C153911025 @default.
- W2034472018 hasConcept C170493617 @default.
- W2034472018 hasConcept C180754005 @default.
- W2034472018 hasConcept C185592680 @default.
- W2034472018 hasConcept C188280979 @default.
- W2034472018 hasConcept C203014093 @default.
- W2034472018 hasConcept C2776090121 @default.
- W2034472018 hasConcept C2777575956 @default.
- W2034472018 hasConcept C2779067128 @default.
- W2034472018 hasConcept C54355233 @default.
- W2034472018 hasConcept C71924100 @default.
- W2034472018 hasConcept C83464605 @default.
- W2034472018 hasConcept C86803240 @default.