Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034488813> ?p ?o ?g. }
- W2034488813 endingPage "e42494" @default.
- W2034488813 startingPage "e42494" @default.
- W2034488813 abstract "Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours." @default.
- W2034488813 created "2016-06-24" @default.
- W2034488813 creator A5005382034 @default.
- W2034488813 creator A5010920098 @default.
- W2034488813 creator A5011732363 @default.
- W2034488813 creator A5020299093 @default.
- W2034488813 creator A5028054823 @default.
- W2034488813 creator A5030827550 @default.
- W2034488813 creator A5035054317 @default.
- W2034488813 creator A5044887899 @default.
- W2034488813 creator A5046329734 @default.
- W2034488813 creator A5046963843 @default.
- W2034488813 creator A5049812833 @default.
- W2034488813 creator A5064016844 @default.
- W2034488813 creator A5070674443 @default.
- W2034488813 creator A5077805370 @default.
- W2034488813 creator A5079950719 @default.
- W2034488813 creator A5086302273 @default.
- W2034488813 date "2012-08-07" @default.
- W2034488813 modified "2023-10-18" @default.
- W2034488813 title "Mouse p53-Deficient Cancer Models as Platforms for Obtaining Genomic Predictors of Human Cancer Clinical Outcomes" @default.
- W2034488813 cites W1607267312 @default.
- W2034488813 cites W1611210979 @default.
- W2034488813 cites W1971465952 @default.
- W2034488813 cites W1979483425 @default.
- W2034488813 cites W1982740705 @default.
- W2034488813 cites W1983686302 @default.
- W2034488813 cites W1992344065 @default.
- W2034488813 cites W1992817971 @default.
- W2034488813 cites W1994488152 @default.
- W2034488813 cites W1998096683 @default.
- W2034488813 cites W2000570199 @default.
- W2034488813 cites W2002091909 @default.
- W2034488813 cites W2012238149 @default.
- W2034488813 cites W2016966976 @default.
- W2034488813 cites W2017239599 @default.
- W2034488813 cites W2022770843 @default.
- W2034488813 cites W2024848743 @default.
- W2034488813 cites W2026433475 @default.
- W2034488813 cites W2028236537 @default.
- W2034488813 cites W2044217732 @default.
- W2034488813 cites W2047446484 @default.
- W2034488813 cites W2050561526 @default.
- W2034488813 cites W2065141010 @default.
- W2034488813 cites W2071595801 @default.
- W2034488813 cites W2073759231 @default.
- W2034488813 cites W2075106626 @default.
- W2034488813 cites W2082668371 @default.
- W2034488813 cites W2084764212 @default.
- W2034488813 cites W2088160256 @default.
- W2034488813 cites W2089370460 @default.
- W2034488813 cites W2089686996 @default.
- W2034488813 cites W2093909277 @default.
- W2034488813 cites W2096079397 @default.
- W2034488813 cites W2101379344 @default.
- W2034488813 cites W2101657563 @default.
- W2034488813 cites W2103174054 @default.
- W2034488813 cites W2105025219 @default.
- W2034488813 cites W2110719738 @default.
- W2034488813 cites W2114408324 @default.
- W2034488813 cites W2117692326 @default.
- W2034488813 cites W2118949116 @default.
- W2034488813 cites W2120865735 @default.
- W2034488813 cites W2121604817 @default.
- W2034488813 cites W2122608679 @default.
- W2034488813 cites W2125789330 @default.
- W2034488813 cites W2131994307 @default.
- W2034488813 cites W2132165198 @default.
- W2034488813 cites W2134964552 @default.
- W2034488813 cites W2135548733 @default.
- W2034488813 cites W2135754261 @default.
- W2034488813 cites W2137761597 @default.
- W2034488813 cites W2139522545 @default.
- W2034488813 cites W2141396204 @default.
- W2034488813 cites W2144465725 @default.
- W2034488813 cites W2145047343 @default.
- W2034488813 cites W2147442577 @default.
- W2034488813 cites W2150533948 @default.
- W2034488813 cites W2150671673 @default.
- W2034488813 cites W2156486984 @default.
- W2034488813 cites W2158501247 @default.
- W2034488813 cites W2160368760 @default.
- W2034488813 cites W2160450758 @default.
- W2034488813 cites W2163563958 @default.
- W2034488813 cites W2165582413 @default.
- W2034488813 cites W2166282686 @default.
- W2034488813 cites W2166869851 @default.
- W2034488813 cites W2167371528 @default.
- W2034488813 cites W2170989872 @default.
- W2034488813 cites W2321245157 @default.
- W2034488813 cites W328827535 @default.
- W2034488813 doi "https://doi.org/10.1371/journal.pone.0042494" @default.
- W2034488813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3413665" @default.
- W2034488813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22880004" @default.
- W2034488813 hasPublicationYear "2012" @default.
- W2034488813 type Work @default.
- W2034488813 sameAs 2034488813 @default.
- W2034488813 citedByCount "7" @default.