Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034489898> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2034489898 endingPage "837" @default.
- W2034489898 startingPage "833" @default.
- W2034489898 abstract "Cimetidine is widely prescribed as a palliative or cure for gastric disorders in man. It is known to be noncarcinogenic to rodents and has been shown to be inactive in a wide range of in vitro and in vivo genotoxicity assays. It was therefore of concern when an injectable formulation of this drug (Cimetex) was reported to initiate UDS in cultured primary rat hepatocytes [Martelli et al, 1983]. We have confirmed the ability of Cimetex to elicit UDS in primary hepatocytes and established that cimetidine itself is inactive. These data indicate that it is not cimetidine per se, but rather its protonated formulation which is responsible for the activity. These observations pose fundamental questions regarding the validity of the UDS end-point when testing salts in vitro, rather than presenting a challenge to the nongenotoxic status of cimetidine." @default.
- W2034489898 created "2016-06-24" @default.
- W2034489898 creator A5061001358 @default.
- W2034489898 creator A5069543282 @default.
- W2034489898 date "1985-01-01" @default.
- W2034489898 modified "2023-09-25" @default.
- W2034489898 title "Investigations into the reported ability of cimetidine to initiate UDS in rat hepatocyte primary cultures" @default.
- W2034489898 cites W1605682187 @default.
- W2034489898 cites W1965160330 @default.
- W2034489898 cites W1965852730 @default.
- W2034489898 cites W1967460021 @default.
- W2034489898 cites W1987541942 @default.
- W2034489898 cites W2020836797 @default.
- W2034489898 cites W2038675287 @default.
- W2034489898 cites W2045672043 @default.
- W2034489898 cites W2069866944 @default.
- W2034489898 cites W2109605610 @default.
- W2034489898 cites W2112483257 @default.
- W2034489898 cites W4254037329 @default.
- W2034489898 doi "https://doi.org/10.1002/em.2860070605" @default.
- W2034489898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4065060" @default.
- W2034489898 hasPublicationYear "1985" @default.
- W2034489898 type Work @default.
- W2034489898 sameAs 2034489898 @default.
- W2034489898 citedByCount "17" @default.
- W2034489898 countsByYear W20344898982019 @default.
- W2034489898 crossrefType "journal-article" @default.
- W2034489898 hasAuthorship W2034489898A5061001358 @default.
- W2034489898 hasAuthorship W2034489898A5069543282 @default.
- W2034489898 hasConcept C121332964 @default.
- W2034489898 hasConcept C126322002 @default.
- W2034489898 hasConcept C1276947 @default.
- W2034489898 hasConcept C185592680 @default.
- W2034489898 hasConcept C202751555 @default.
- W2034489898 hasConcept C207001950 @default.
- W2034489898 hasConcept C2776200302 @default.
- W2034489898 hasConcept C2777977315 @default.
- W2034489898 hasConcept C2778959862 @default.
- W2034489898 hasConcept C2780035454 @default.
- W2034489898 hasConcept C2780719153 @default.
- W2034489898 hasConcept C29730261 @default.
- W2034489898 hasConcept C2994367422 @default.
- W2034489898 hasConcept C54355233 @default.
- W2034489898 hasConcept C55493867 @default.
- W2034489898 hasConcept C71924100 @default.
- W2034489898 hasConcept C86803240 @default.
- W2034489898 hasConcept C98274493 @default.
- W2034489898 hasConceptScore W2034489898C121332964 @default.
- W2034489898 hasConceptScore W2034489898C126322002 @default.
- W2034489898 hasConceptScore W2034489898C1276947 @default.
- W2034489898 hasConceptScore W2034489898C185592680 @default.
- W2034489898 hasConceptScore W2034489898C202751555 @default.
- W2034489898 hasConceptScore W2034489898C207001950 @default.
- W2034489898 hasConceptScore W2034489898C2776200302 @default.
- W2034489898 hasConceptScore W2034489898C2777977315 @default.
- W2034489898 hasConceptScore W2034489898C2778959862 @default.
- W2034489898 hasConceptScore W2034489898C2780035454 @default.
- W2034489898 hasConceptScore W2034489898C2780719153 @default.
- W2034489898 hasConceptScore W2034489898C29730261 @default.
- W2034489898 hasConceptScore W2034489898C2994367422 @default.
- W2034489898 hasConceptScore W2034489898C54355233 @default.
- W2034489898 hasConceptScore W2034489898C55493867 @default.
- W2034489898 hasConceptScore W2034489898C71924100 @default.
- W2034489898 hasConceptScore W2034489898C86803240 @default.
- W2034489898 hasConceptScore W2034489898C98274493 @default.
- W2034489898 hasIssue "6" @default.
- W2034489898 hasLocation W20344898981 @default.
- W2034489898 hasLocation W20344898982 @default.
- W2034489898 hasOpenAccess W2034489898 @default.
- W2034489898 hasPrimaryLocation W20344898981 @default.
- W2034489898 hasRelatedWork W1500348095 @default.
- W2034489898 hasRelatedWork W1516855358 @default.
- W2034489898 hasRelatedWork W1976240823 @default.
- W2034489898 hasRelatedWork W2038675287 @default.
- W2034489898 hasRelatedWork W2077473403 @default.
- W2034489898 hasRelatedWork W2325795327 @default.
- W2034489898 hasRelatedWork W2352627136 @default.
- W2034489898 hasRelatedWork W2414358148 @default.
- W2034489898 hasRelatedWork W2433311123 @default.
- W2034489898 hasRelatedWork W2896492254 @default.
- W2034489898 hasVolume "7" @default.
- W2034489898 isParatext "false" @default.
- W2034489898 isRetracted "false" @default.
- W2034489898 magId "2034489898" @default.
- W2034489898 workType "article" @default.