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• W2034490611 abstract "The regulatory role of arginine vasotocin (AVT) and isotocin (IT) in Cl− secretion was investigated with the short circuit current (Isc) technique in opercular epithelia of killifish (Fundulus heteroclitus) and gilthead sea bream (Sparus aurata). Sea bream operculum showed ~ 4-fold lower number of Na/K-ATPase immunoreactive cells and ~ 12-fold lower secretory current than the killifish. In sea bream opercular membranes, the basolateral addition of AVT (10− 6 M) significantly stimulated Cl− secretion, while IT (10− 6 M) was without effect. In killifish, IT produced an immediate dose-dependent stimulation of Cl− secretion with significant effect at doses ≥ 10− 7 M and stimulation maxima (∆Isc ~ 25 μA ⋅ cm− 2) at 10− 6 M. The basolateral addition of bumetanide (200 μM) abolished > 75% of the effect of IT on Cl− secretion. In turn, AVT had a dual effect on killifish opercular Isc: an immediate response (~ 3 min) with Isc reduction in an inverted bell-shaped dose–response manner with higher current decrease (− 22 μA ⋅ cm− 2) at 10− 8 M AVT, and a sustained dose-dependent stimulation of Cl− secretion (stable up to 1 h), with a threshold significant effect at 10− 8 M and maximal stimulation (~ 20 μA ⋅ cm− 2) at 10− 6 M. Both effects of AVT appear receptor type specific. The V1-receptor antagonist SR 49059 abolished Isc reduction in response to AVT, while the specific V2-receptor antagonist (Tolvaptan, 1 μM) abolished the stimulatory action of AVT on Cl− secretion. According to these results, we propose a modulatory role for AVT and IT in Cl− (NaCl) secretion across the opercular epithelium of marine teleost." @default.
• W2034490611 created "2016-06-24" @default.
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• W2034490611 date "2015-04-01" @default.
• W2034490611 modified "2023-10-18" @default.
• W2034490611 title "AVT and IT regulate ion transport across the opercular epithelium of killifish ( Fundulus heteroclitus ) and gilthead sea bream ( Sparus aurata )" @default.
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• W2034490611 doi "https://doi.org/10.1016/j.cbpa.2014.12.027" @default.
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