FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034493802> ?p ?o ?g. }

• W2034493802 endingPage "635" @default.
• W2034493802 startingPage "615" @default.
• W2034493802 abstract "In vitro, expanded neurospheres exhibit multipotent properties and can differentiate into neurons, astrocytes and oligodendrocytes. In vivo, cells from neurospheres derived from mouse fetal forebrain have previously been reported to predominantly differentiate into glial cells, and not into neurons. Here we isolated stem/progenitor cells from E13.5 lateral ganglionic eminence (LGE), medial ganglionic eminence (MGE) and cortical primordium, of a green fluorescent protein (GFP)-actin transgenic mouse. Free-floating neurospheres were expanded in the presence of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) and implanted after five to six passages into the striatum, hippocampus and cortex of neonatal rats. Cell suspensions of primary LGE tissue were prepared and grafted in parallel. Grafted cells derived from the primary tissue displayed widespread incorporation into all regions, as visualized with the mouse-specific antibody M2, or mouse satellite DNA in situ hybridization, and differentiated into both neurons, astrocytes and oligodendrocytes. Grafts of neurosphere cells derived from the LGE, MGE and cortical primordium differentiated primarily into astrocytes, but contained low but significant numbers of GFP-immunoreactive neurons. Neurons derived from LGE neurospheres were of three types: cells with the morphology of medium-sized densely spiny projection neurons in the striatum; cells with interneuron-like morphologies in striatum, cortex and hippocampus; and cells integrating into SVZ and migrating along the RMS to the olfactory bulb. MGE- or cortical primordium-derived neurospheres differentiated into interneuron-like cells in both striatum and hippocampus. The results demonstrate the ability of in vitro expanded neural stem/progenitor cells to generate both neurons and glia after transplantation into neonatal recipients, and differentiate in a region-specific manner into mature neurons with morphological features characteristic for each target site." @default.
• W2034493802 created "2016-06-24" @default.
• W2034493802 creator A5047762447 @default.
• W2034493802 creator A5048838160 @default.
• W2034493802 creator A5073255074 @default.
• W2034493802 date "2003-12-01" @default.
• W2034493802 modified "2023-09-24" @default.
• W2034493802 title "Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions" @default.
• W2034493802 cites W1479736082 @default.
• W2034493802 cites W1514839961 @default.
• W2034493802 cites W1517182551 @default.
• W2034493802 cites W1520969765 @default.
• W2034493802 cites W1580707798 @default.
• W2034493802 cites W1589246521 @default.
• W2034493802 cites W1595834812 @default.
• W2034493802 cites W161467701 @default.
• W2034493802 cites W1826719783 @default.
• W2034493802 cites W1875709550 @default.
• W2034493802 cites W1943950513 @default.
• W2034493802 cites W1966070964 @default.
• W2034493802 cites W1983482520 @default.
• W2034493802 cites W1985236579 @default.
• W2034493802 cites W1986209719 @default.
• W2034493802 cites W1989266013 @default.
• W2034493802 cites W1995658302 @default.
• W2034493802 cites W1996396562 @default.
• W2034493802 cites W1997857277 @default.
• W2034493802 cites W1998862379 @default.
• W2034493802 cites W1999689089 @default.
• W2034493802 cites W1999747064 @default.
• W2034493802 cites W2000029352 @default.
• W2034493802 cites W2000156766 @default.
• W2034493802 cites W2004587984 @default.
• W2034493802 cites W2007986826 @default.
• W2034493802 cites W2019215467 @default.
• W2034493802 cites W2023195093 @default.
• W2034493802 cites W2030574517 @default.
• W2034493802 cites W2032579724 @default.
• W2034493802 cites W2032928589 @default.
• W2034493802 cites W2035267175 @default.
• W2034493802 cites W2035831169 @default.
• W2034493802 cites W2039192678 @default.
• W2034493802 cites W2041149604 @default.
• W2034493802 cites W2048833489 @default.
• W2034493802 cites W2057099486 @default.
• W2034493802 cites W2072239664 @default.
• W2034493802 cites W2075281619 @default.
• W2034493802 cites W2079356804 @default.
• W2034493802 cites W2081597955 @default.
• W2034493802 cites W2081768529 @default.
• W2034493802 cites W2084652820 @default.
• W2034493802 cites W2095129531 @default.
• W2034493802 cites W2097053397 @default.
• W2034493802 cites W2097454127 @default.
• W2034493802 cites W2105013029 @default.
• W2034493802 cites W2117342602 @default.
• W2034493802 cites W2127535417 @default.
• W2034493802 cites W2140536312 @default.
• W2034493802 cites W2141998956 @default.
• W2034493802 cites W2150817988 @default.
• W2034493802 cites W2159617943 @default.
• W2034493802 cites W2161687882 @default.
• W2034493802 cites W2226542764 @default.
• W2034493802 cites W333755041 @default.
• W2034493802 cites W4233933472 @default.
• W2034493802 doi "https://doi.org/10.1016/s0014-4886(03)00271-1" @default.
• W2034493802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14769354" @default.
• W2034493802 hasPublicationYear "2003" @default.
• W2034493802 type Work @default.
• W2034493802 sameAs 2034493802 @default.
• W2034493802 citedByCount "76" @default.
• W2034493802 countsByYear W20344938022012 @default.
• W2034493802 countsByYear W20344938022013 @default.
• W2034493802 countsByYear W20344938022014 @default.
• W2034493802 countsByYear W20344938022015 @default.
• W2034493802 countsByYear W20344938022016 @default.
• W2034493802 countsByYear W20344938022017 @default.
• W2034493802 countsByYear W20344938022019 @default.
• W2034493802 countsByYear W20344938022020 @default.
• W2034493802 countsByYear W20344938022022 @default.
• W2034493802 crossrefType "journal-article" @default.
• W2034493802 hasAuthorship W2034493802A5047762447 @default.
• W2034493802 hasAuthorship W2034493802A5048838160 @default.
• W2034493802 hasAuthorship W2034493802A5073255074 @default.
• W2034493802 hasConcept C104317684 @default.
• W2034493802 hasConcept C126322002 @default.
• W2034493802 hasConcept C136834591 @default.
• W2034493802 hasConcept C145103041 @default.
• W2034493802 hasConcept C162746124 @default.
• W2034493802 hasConcept C169760540 @default.
• W2034493802 hasConcept C17077164 @default.
• W2034493802 hasConcept C201750760 @default.
• W2034493802 hasConcept C20875687 @default.
• W2034493802 hasConcept C2777542384 @default.
• W2034493802 hasConcept C2779296341 @default.
• W2034493802 hasConcept C2779715522 @default.
• W2034493802 hasConcept C2780597806 @default.
• W2034493802 hasConcept C28328180 @default.

• next