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- W2034497389 abstract "Low expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase gene during development correlates with an unusually low hepatic ketogenic capacity and lack of hyperketonaemia in piglets. Here we report the isolation and characterization of the 5´ end of the pig mitochondrial HMG-CoA synthase gene. The 581 bp region proximal to the transcription start site permits transcription of a reporter gene, confirming the function of the promoter. The pig mitochondrial HMG-CoA synthase promoter is trans-activated by the peroxisomal proliferator-activated receptor (PPAR), and a functional response element for PPAR (PPRE) has been localized in the promoter region. Pig PPRE is constituted by an imperfect direct repeat (DR-1) and a downstream sequence, both of which are needed to confer PPAR-sensitivity to a thymidine kinase promoter and to form complexes with PPAR·retinoid X receptor heterodimers. A role of PPAR trans-activation in starvation-associated induction of gene expression is suggested." @default.
- W2034497389 created "2016-06-24" @default.
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- W2034497389 date "1999-01-08" @default.
- W2034497389 modified "2023-10-17" @default.
- W2034497389 title "Isolation of pig mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene promoter: characterization of a peroxisome proliferator-responsive element" @default.
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- W2034497389 doi "https://doi.org/10.1042/bj3370329" @default.
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