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- W2034499230 abstract "The entire hematopoietic system in all its complexity arises from a small number of stem cells that not only differentiate but also replenish the bone marrow by a process of self-renewal. These stem cells supply the marrow with committed progenitor cells that become the main hematopoietic cell types. Cells that move beyond the progenitor stage lose their capacity for self-renewal but retain the potential to differentiate into erythrocytes, granulocytes, monocytes, megakaryocytes, or lymphocytes. The idea that a stem cell or one of its immediate descendants is the source of hematopoietic neoplasms has ramifications for all types of cancer. A lesion . . ." @default.
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- W2034499230 date "1990-03-08" @default.
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- W2034499230 title "Cellular Origins of Hematologic Neoplasms" @default.
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- W2034499230 doi "https://doi.org/10.1056/nejm199003083221011" @default.
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